from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0710/rpsQ

LFCtreatmentdescriptionclass of inhibitor

-1.459

Amikacinug/mL Amikacintranslation

-1.522

Cap5-10ug/mL Capreomycintranslation

-2.038

Rox10-50 ug/mL Roxithromycintranslation

0.139

SM2-5 ug/mL Streptomycintranslation

-1.677

Tet5-10 ug/mL Tetracyclinetranslation

-0.844

Rif0.2-5ug/mL Rifampicintranscription

-0.148

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.374

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.435

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.513

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.712

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.382

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.850

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.205

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.505

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.593

Nigericin50 uM Nigericinrespiration

-0.882

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.950

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.910

menadione6-10 ug/mL Menadionerespiration

-0.253

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.601

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.678

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.159

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.224

NRP_1Non-replicating persistence stage 1dosRassociated

0.458

Amp0.2mg/mL AmpicillincellWall

0.761

Cephalexin20-100 ug/mL CephalexincellWall

0.685

Cerulenin0.32-5 ug/mL CerulenincellWall

0.328

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.161

EMB10-20 ug/mL EthambutolcellWall

0.088

Eta12-40 ug/mL EthionamidecellWall

0.530

INH0.2-0.4 ug/mL IsoniazidcellWall

0.247

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.540

BZA0.12 mg/mL BenzamidearomaticAmides

-0.320

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.128

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.449

H2O24 mM hydrogen peroxideDNAdamaging

0.680

Levo10 ug/mL LevofloxacinDNAdamaging

0.921

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.314

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.889

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.436

Antimycin12.5-50 ug/mL Antimycin A?

0.711

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.181

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.162

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.561

PA8240.2-2 ug/mL PA-824?

-1.656

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.174

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.783

Verapamil50 uM Verapamil?

0.764

mercaptoethanol2 mM 2-Mercaptoethanol?

2.380

methoxatin10-20 ug/mL Methoxatin?