from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0703/rplW

LFCtreatmentdescriptionclass of inhibitor

0.691

Amikacinug/mL Amikacintranslation

1.055

Cap5-10ug/mL Capreomycintranslation

1.790

Rox10-50 ug/mL Roxithromycintranslation

0.986

SM2-5 ug/mL Streptomycintranslation

1.525

Tet5-10 ug/mL Tetracyclinetranslation

-0.266

Rif0.2-5ug/mL Rifampicintranscription

0.356

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.244

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.526

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.786

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.119

Clofazimine10-13 ug/mL Clofaziminerespiration

0.122

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.052

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.144

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.837

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.256

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.954

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.732

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.252

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.401

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.893

KCN5-20 ug/mL Potassium cyaniderespiration

-1.312

NaN30.2-2 mM Sodium aziderespiration

0.350

Nigericin50 uM Nigericinrespiration

-0.719

TRC10-150 ug/mL Triclosanrespiration

-1.555

TRZ10-25 ug/mL Thioridazinerespiration

1.457

Valinomycin0.5-10 uM Valinomycinrespiration

0.370

ZnSO42 mM ZnSO4respiration

-0.294

menadione6-10 ug/mL Menadionerespiration

-0.256

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.625

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.434

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.597

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.505

NRP_1Non-replicating persistence stage 1dosRassociated

0.729

Amp0.2mg/mL AmpicillincellWall

0.609

Cephalexin20-100 ug/mL CephalexincellWall

0.470

Cerulenin0.32-5 ug/mL CerulenincellWall

0.773

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.342

EMB10-20 ug/mL EthambutolcellWall

0.131

Eta12-40 ug/mL EthionamidecellWall

0.486

INH0.2-0.4 ug/mL IsoniazidcellWall

0.303

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.266

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.499

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.247

BZA0.12 mg/mL BenzamidearomaticAmides

0.149

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.341

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.220

H2O24 mM hydrogen peroxideDNAdamaging

1.045

Levo10 ug/mL LevofloxacinDNAdamaging

0.760

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.184

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.832

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.639

UVUV-irradiationDNAdamaging

-1.063

ARP41-4 ug/mL Antitubercular compound ARP4?

0.572

Antimycin12.5-50 ug/mL Antimycin A?

0.407

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.368

PA_110-50 ug/mL Antitubercular compound PA-1?

0.594

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.416

PA8240.2-2 ug/mL PA-824?

-1.458

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.189

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.247

Verapamil50 uM Verapamil?

0.227

mercaptoethanol2 mM 2-Mercaptoethanol?

0.625

methoxatin10-20 ug/mL Methoxatin?