from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0700/rpsJ

LFCtreatmentdescriptionclass of inhibitor

1.672

Amikacinug/mL Amikacintranslation

1.539

Cap5-10ug/mL Capreomycintranslation

1.747

Rox10-50 ug/mL Roxithromycintranslation

1.107

SM2-5 ug/mL Streptomycintranslation

1.818

Tet5-10 ug/mL Tetracyclinetranslation

-0.967

Rif0.2-5ug/mL Rifampicintranscription

-0.721

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.725

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.512

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.627

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.631

Clofazimine10-13 ug/mL Clofaziminerespiration

0.257

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.298

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.970

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.913

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.105

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.902

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.237

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.071

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.569

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.995

KCN5-20 ug/mL Potassium cyaniderespiration

-1.403

NaN30.2-2 mM Sodium aziderespiration

0.522

Nigericin50 uM Nigericinrespiration

-1.514

TRC10-150 ug/mL Triclosanrespiration

-1.218

TRZ10-25 ug/mL Thioridazinerespiration

1.200

Valinomycin0.5-10 uM Valinomycinrespiration

0.504

ZnSO42 mM ZnSO4respiration

-0.188

menadione6-10 ug/mL Menadionerespiration

-0.153

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.493

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.187

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.461

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.079

NRP_1Non-replicating persistence stage 1dosRassociated

0.967

Amp0.2mg/mL AmpicillincellWall

0.378

Cephalexin20-100 ug/mL CephalexincellWall

0.573

Cerulenin0.32-5 ug/mL CerulenincellWall

0.540

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.352

EMB10-20 ug/mL EthambutolcellWall

-0.021

Eta12-40 ug/mL EthionamidecellWall

0.652

INH0.2-0.4 ug/mL IsoniazidcellWall

0.179

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.178

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.414

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.485

BZA0.12 mg/mL BenzamidearomaticAmides

-0.006

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.066

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.248

H2O24 mM hydrogen peroxideDNAdamaging

1.169

Levo10 ug/mL LevofloxacinDNAdamaging

1.071

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.181

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.136

Oflox5-10 ug/mL OfloxacinDNAdamaging

1.321

UVUV-irradiationDNAdamaging

-0.970

ARP41-4 ug/mL Antitubercular compound ARP4?

0.415

Antimycin12.5-50 ug/mL Antimycin A?

0.397

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.044

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.078

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.770

PA8240.2-2 ug/mL PA-824?

-1.013

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.238

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.418

Verapamil50 uM Verapamil?

0.356

mercaptoethanol2 mM 2-Mercaptoethanol?

0.630

methoxatin10-20 ug/mL Methoxatin?