from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0692/-

LFCtreatmentdescriptionclass of inhibitor

1.779

Amikacinug/mL Amikacintranslation

1.183

Cap5-10ug/mL Capreomycintranslation

1.433

Rox10-50 ug/mL Roxithromycintranslation

0.922

SM2-5 ug/mL Streptomycintranslation

0.940

Tet5-10 ug/mL Tetracyclinetranslation

-1.162

Rif0.2-5ug/mL Rifampicintranscription

-0.266

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.158

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.476

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.114

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.359

Clofazimine10-13 ug/mL Clofaziminerespiration

0.324

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.989

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.776

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.201

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.255

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.927

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.292

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.191

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.785

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.351

KCN5-20 ug/mL Potassium cyaniderespiration

-1.084

NaN30.2-2 mM Sodium aziderespiration

0.434

Nigericin50 uM Nigericinrespiration

-0.894

TRC10-150 ug/mL Triclosanrespiration

-0.639

TRZ10-25 ug/mL Thioridazinerespiration

-1.014

Valinomycin0.5-10 uM Valinomycinrespiration

0.908

ZnSO42 mM ZnSO4respiration

-0.701

menadione6-10 ug/mL Menadionerespiration

0.293

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.599

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.254

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.618

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.048

NRP_1Non-replicating persistence stage 1dosRassociated

0.632

Amp0.2mg/mL AmpicillincellWall

0.184

Cephalexin20-100 ug/mL CephalexincellWall

0.284

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.084

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.110

EMB10-20 ug/mL EthambutolcellWall

0.884

Eta12-40 ug/mL EthionamidecellWall

0.900

INH0.2-0.4 ug/mL IsoniazidcellWall

0.415

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.067

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.032

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.152

BZA0.12 mg/mL BenzamidearomaticAmides

-0.457

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.701

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.292

H2O24 mM hydrogen peroxideDNAdamaging

-0.514

Levo10 ug/mL LevofloxacinDNAdamaging

0.363

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.321

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.697

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.258

UVUV-irradiationDNAdamaging

-0.539

ARP41-4 ug/mL Antitubercular compound ARP4?

1.321

Antimycin12.5-50 ug/mL Antimycin A?

0.597

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.631

PA_110-50 ug/mL Antitubercular compound PA-1?

0.579

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.361

PA8240.2-2 ug/mL PA-824?

-1.406

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.989

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.605

Verapamil50 uM Verapamil?

2.037

mercaptoethanol2 mM 2-Mercaptoethanol?

0.644

methoxatin10-20 ug/mL Methoxatin?