from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0682/rpsL

LFCtreatmentdescriptionclass of inhibitor

0.618

Amikacinug/mL Amikacintranslation

1.356

Cap5-10ug/mL Capreomycintranslation

1.270

Rox10-50 ug/mL Roxithromycintranslation

1.128

SM2-5 ug/mL Streptomycintranslation

0.599

Tet5-10 ug/mL Tetracyclinetranslation

-1.472

Rif0.2-5ug/mL Rifampicintranscription

-1.227

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.711

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.785

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.594

CPZ10-50 ug/mL Chlorpromazinerespiration

0.262

Clofazimine10-13 ug/mL Clofaziminerespiration

0.127

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.511

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.901

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.076

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.145

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.018

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.889

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.215

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.045

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.334

KCN5-20 ug/mL Potassium cyaniderespiration

-0.787

NaN30.2-2 mM Sodium aziderespiration

1.236

Nigericin50 uM Nigericinrespiration

-1.973

TRC10-150 ug/mL Triclosanrespiration

-0.856

TRZ10-25 ug/mL Thioridazinerespiration

1.919

Valinomycin0.5-10 uM Valinomycinrespiration

0.772

ZnSO42 mM ZnSO4respiration

0.500

menadione6-10 ug/mL Menadionerespiration

0.041

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.384

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.008

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.520

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.741

NRP_1Non-replicating persistence stage 1dosRassociated

0.300

Amp0.2mg/mL AmpicillincellWall

-0.057

Cephalexin20-100 ug/mL CephalexincellWall

0.581

Cerulenin0.32-5 ug/mL CerulenincellWall

0.139

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.256

EMB10-20 ug/mL EthambutolcellWall

0.065

Eta12-40 ug/mL EthionamidecellWall

0.266

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.219

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.174

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.036

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.009

BZA0.12 mg/mL BenzamidearomaticAmides

0.261

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.181

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.020

H2O24 mM hydrogen peroxideDNAdamaging

0.631

Levo10 ug/mL LevofloxacinDNAdamaging

0.775

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.031

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.581

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.997

UVUV-irradiationDNAdamaging

-0.770

ARP41-4 ug/mL Antitubercular compound ARP4?

0.046

Antimycin12.5-50 ug/mL Antimycin A?

0.413

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.101

PA_110-50 ug/mL Antitubercular compound PA-1?

0.023

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.473

PA8240.2-2 ug/mL PA-824?

-0.883

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.131

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.920

Verapamil50 uM Verapamil?

0.241

mercaptoethanol2 mM 2-Mercaptoethanol?

0.242

methoxatin10-20 ug/mL Methoxatin?