from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0651/rplJ

LFCtreatmentdescriptionclass of inhibitor

2.490

Amikacinug/mL Amikacintranslation

2.942

Cap5-10ug/mL Capreomycintranslation

2.379

Rox10-50 ug/mL Roxithromycintranslation

1.519

SM2-5 ug/mL Streptomycintranslation

3.745

Tet5-10 ug/mL Tetracyclinetranslation

-0.196

Rif0.2-5ug/mL Rifampicintranscription

0.338

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.547

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.256

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.938

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.966

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.336

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.812

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.337

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.955

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.556

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.747

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.242

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.252

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.207

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.351

KCN5-20 ug/mL Potassium cyaniderespiration

-0.976

NaN30.2-2 mM Sodium aziderespiration

1.173

Nigericin50 uM Nigericinrespiration

-0.311

TRC10-150 ug/mL Triclosanrespiration

-1.566

TRZ10-25 ug/mL Thioridazinerespiration

-0.423

Valinomycin0.5-10 uM Valinomycinrespiration

0.805

ZnSO42 mM ZnSO4respiration

-0.293

menadione6-10 ug/mL Menadionerespiration

-0.386

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.653

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.175

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.627

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.350

NRP_1Non-replicating persistence stage 1dosRassociated

0.561

Amp0.2mg/mL AmpicillincellWall

0.616

Cephalexin20-100 ug/mL CephalexincellWall

0.817

Cerulenin0.32-5 ug/mL CerulenincellWall

0.385

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.394

EMB10-20 ug/mL EthambutolcellWall

0.262

Eta12-40 ug/mL EthionamidecellWall

0.778

INH0.2-0.4 ug/mL IsoniazidcellWall

0.285

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.135

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.131

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.372

BZA0.12 mg/mL BenzamidearomaticAmides

-0.079

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.281

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.104

H2O24 mM hydrogen peroxideDNAdamaging

0.541

Levo10 ug/mL LevofloxacinDNAdamaging

0.748

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.498

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.486

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.706

UVUV-irradiationDNAdamaging

-1.042

ARP41-4 ug/mL Antitubercular compound ARP4?

0.324

Antimycin12.5-50 ug/mL Antimycin A?

0.422

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.146

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.240

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.350

PA8240.2-2 ug/mL PA-824?

-0.729

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.429

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.144

Verapamil50 uM Verapamil?

-0.055

mercaptoethanol2 mM 2-Mercaptoethanol?

0.543

methoxatin10-20 ug/mL Methoxatin?