from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0619/galTb

LFCtreatmentdescriptionclass of inhibitor

-0.942

Amikacinug/mL Amikacintranslation

-0.528

Cap5-10ug/mL Capreomycintranslation

-0.941

Rox10-50 ug/mL Roxithromycintranslation

0.610

SM2-5 ug/mL Streptomycintranslation

-1.654

Tet5-10 ug/mL Tetracyclinetranslation

1.002

Rif0.2-5ug/mL Rifampicintranscription

0.190

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.103

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.140

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.621

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.036

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-2.254

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.481

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-2.523

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.098

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.677

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.156

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.625

Nigericin50 uM Nigericinrespiration

0.338

TRC10-150 ug/mL Triclosanrespiration

0.541

TRZ10-25 ug/mL Thioridazinerespiration

-0.777

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-3.553

menadione6-10 ug/mL Menadionerespiration

-0.202

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.389

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.125

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.033

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.522

NRP_1Non-replicating persistence stage 1dosRassociated

-0.138

Amp0.2mg/mL AmpicillincellWall

-0.421

Cephalexin20-100 ug/mL CephalexincellWall

0.221

Cerulenin0.32-5 ug/mL CerulenincellWall

1.265

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.246

EMB10-20 ug/mL EthambutolcellWall

-0.242

Eta12-40 ug/mL EthionamidecellWall

-0.308

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.121

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.218

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.207

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.501

BZA0.12 mg/mL BenzamidearomaticAmides

0.079

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.503

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.011

H2O24 mM hydrogen peroxideDNAdamaging

0.422

Levo10 ug/mL LevofloxacinDNAdamaging

-0.512

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.993

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.178

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.530

UVUV-irradiationDNAdamaging

0.142

ARP41-4 ug/mL Antitubercular compound ARP4?

0.645

Antimycin12.5-50 ug/mL Antimycin A?

-0.722

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.368

PA_110-50 ug/mL Antitubercular compound PA-1?

1.174

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.133

PA8240.2-2 ug/mL PA-824?

0.950

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.028

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-2.617

Verapamil50 uM Verapamil?

-2.200

mercaptoethanol2 mM 2-Mercaptoethanol?

0.291

methoxatin10-20 ug/mL Methoxatin?