from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0618/galTa

LFCtreatmentdescriptionclass of inhibitor

-0.362

Amikacinug/mL Amikacintranslation

-0.451

Cap5-10ug/mL Capreomycintranslation

0.002

Rox10-50 ug/mL Roxithromycintranslation

-0.230

SM2-5 ug/mL Streptomycintranslation

-0.193

Tet5-10 ug/mL Tetracyclinetranslation

0.359

Rif0.2-5ug/mL Rifampicintranscription

-0.083

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.310

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.251

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-1.016

CPZ10-50 ug/mL Chlorpromazinerespiration

0.359

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.507

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.129

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.332

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.477

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.162

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.165

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.261

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.965

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.432

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.055

KCN5-20 ug/mL Potassium cyaniderespiration

-0.543

NaN30.2-2 mM Sodium aziderespiration

-0.284

Nigericin50 uM Nigericinrespiration

0.855

TRC10-150 ug/mL Triclosanrespiration

0.654

TRZ10-25 ug/mL Thioridazinerespiration

1.962

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.623

menadione6-10 ug/mL Menadionerespiration

-0.306

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.023

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.110

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.206

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.362

NRP_1Non-replicating persistence stage 1dosRassociated

0.196

Amp0.2mg/mL AmpicillincellWall

0.360

Cephalexin20-100 ug/mL CephalexincellWall

-0.538

Cerulenin0.32-5 ug/mL CerulenincellWall

0.200

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.166

EMB10-20 ug/mL EthambutolcellWall

0.156

Eta12-40 ug/mL EthionamidecellWall

-0.481

INH0.2-0.4 ug/mL IsoniazidcellWall

0.455

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.279

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.622

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.789

BZA0.12 mg/mL BenzamidearomaticAmides

0.441

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.040

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.695

H2O24 mM hydrogen peroxideDNAdamaging

-0.300

Levo10 ug/mL LevofloxacinDNAdamaging

0.385

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.912

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.458

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.010

UVUV-irradiationDNAdamaging

-2.172

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.053

Antimycin12.5-50 ug/mL Antimycin A?

-0.581

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.168

PA_110-50 ug/mL Antitubercular compound PA-1?

0.191

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.512

PA8240.2-2 ug/mL PA-824?

-0.097

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.015

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.485

Verapamil50 uM Verapamil?

-0.343

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.822

methoxatin10-20 ug/mL Methoxatin?