from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0611c/-

LFCtreatmentdescriptionclass of inhibitor

2.310

Amikacinug/mL Amikacintranslation

2.225

Cap5-10ug/mL Capreomycintranslation

2.844

Rox10-50 ug/mL Roxithromycintranslation

-0.174

SM2-5 ug/mL Streptomycintranslation

2.038

Tet5-10 ug/mL Tetracyclinetranslation

1.264

Rif0.2-5ug/mL Rifampicintranscription

-0.701

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.553

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.857

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-1.154

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.341

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.918

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.111

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.253

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.432

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.129

Nigericin50 uM Nigericinrespiration

-0.299

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.978

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.359

menadione6-10 ug/mL Menadionerespiration

0.553

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.097

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.620

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.759

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.048

NRP_1Non-replicating persistence stage 1dosRassociated

-0.267

Amp0.2mg/mL AmpicillincellWall

-0.162

Cephalexin20-100 ug/mL CephalexincellWall

-0.127

Cerulenin0.32-5 ug/mL CerulenincellWall

1.050

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.764

EMB10-20 ug/mL EthambutolcellWall

0.189

Eta12-40 ug/mL EthionamidecellWall

0.806

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.179

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.836

BZA0.12 mg/mL BenzamidearomaticAmides

-0.308

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.408

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.318

H2O24 mM hydrogen peroxideDNAdamaging

-0.817

Levo10 ug/mL LevofloxacinDNAdamaging

-0.326

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.595

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.439

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.467

Antimycin12.5-50 ug/mL Antimycin A?

0.123

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.848

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.339

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.319

PA8240.2-2 ug/mL PA-824?

-0.132

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.110

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

0.121

mercaptoethanol2 mM 2-Mercaptoethanol?

1.000

methoxatin10-20 ug/mL Methoxatin?