from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0607/-

LFCtreatmentdescriptionclass of inhibitor

0.546

Amikacinug/mL Amikacintranslation

1.396

Cap5-10ug/mL Capreomycintranslation

0.748

Rox10-50 ug/mL Roxithromycintranslation

-0.173

SM2-5 ug/mL Streptomycintranslation

1.571

Tet5-10 ug/mL Tetracyclinetranslation

0.335

Rif0.2-5ug/mL Rifampicintranscription

0.367

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.835

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.095

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.017

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.846

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.069

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.258

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.866

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.160

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.049

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.742

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.982

Nigericin50 uM Nigericinrespiration

0.281

TRC10-150 ug/mL Triclosanrespiration

-0.235

TRZ10-25 ug/mL Thioridazinerespiration

0.669

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

1.206

menadione6-10 ug/mL Menadionerespiration

-0.198

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.396

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.307

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.713

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.598

NRP_1Non-replicating persistence stage 1dosRassociated

-1.131

Amp0.2mg/mL AmpicillincellWall

0.443

Cephalexin20-100 ug/mL CephalexincellWall

0.152

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.216

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.864

EMB10-20 ug/mL EthambutolcellWall

-0.434

Eta12-40 ug/mL EthionamidecellWall

-0.627

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.181

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.427

BZA0.12 mg/mL BenzamidearomaticAmides

-0.204

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.530

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.535

H2O24 mM hydrogen peroxideDNAdamaging

1.551

Levo10 ug/mL LevofloxacinDNAdamaging

-0.389

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.526

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.509

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.200

Antimycin12.5-50 ug/mL Antimycin A?

-0.505

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.065

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.306

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.852

PA8240.2-2 ug/mL PA-824?

-0.670

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.219

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-0.852

mercaptoethanol2 mM 2-Mercaptoethanol?

2.193

methoxatin10-20 ug/mL Methoxatin?