from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0572c/-

LFCtreatmentdescriptionclass of inhibitor

0.136

Amikacinug/mL Amikacintranslation

0.962

Cap5-10ug/mL Capreomycintranslation

0.596

Rox10-50 ug/mL Roxithromycintranslation

0.301

SM2-5 ug/mL Streptomycintranslation

0.369

Tet5-10 ug/mL Tetracyclinetranslation

-1.461

Rif0.2-5ug/mL Rifampicintranscription

-0.289

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.355

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.381

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.359

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.028

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.077

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.960

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.566

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.024

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.205

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.357

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.462

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.136

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.841

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.073

KCN5-20 ug/mL Potassium cyaniderespiration

0.047

NaN30.2-2 mM Sodium aziderespiration

0.494

Nigericin50 uM Nigericinrespiration

-1.113

TRC10-150 ug/mL Triclosanrespiration

-0.846

TRZ10-25 ug/mL Thioridazinerespiration

0.608

Valinomycin0.5-10 uM Valinomycinrespiration

0.615

ZnSO42 mM ZnSO4respiration

0.867

menadione6-10 ug/mL Menadionerespiration

-0.037

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.267

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.388

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

2.016

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

3.787

NRP_1Non-replicating persistence stage 1dosRassociated

0.105

Amp0.2mg/mL AmpicillincellWall

0.328

Cephalexin20-100 ug/mL CephalexincellWall

-0.283

Cerulenin0.32-5 ug/mL CerulenincellWall

0.282

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.036

EMB10-20 ug/mL EthambutolcellWall

-0.101

Eta12-40 ug/mL EthionamidecellWall

-0.257

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.202

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.435

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.934

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.408

BZA0.12 mg/mL BenzamidearomaticAmides

-0.251

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.043

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.200

H2O24 mM hydrogen peroxideDNAdamaging

-0.306

Levo10 ug/mL LevofloxacinDNAdamaging

-0.023

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.612

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.198

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.162

UVUV-irradiationDNAdamaging

1.930

ARP41-4 ug/mL Antitubercular compound ARP4?

0.181

Antimycin12.5-50 ug/mL Antimycin A?

0.166

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.468

PA_110-50 ug/mL Antitubercular compound PA-1?

0.982

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.299

PA8240.2-2 ug/mL PA-824?

1.247

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.333

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.014

Verapamil50 uM Verapamil?

0.552

mercaptoethanol2 mM 2-Mercaptoethanol?

0.380

methoxatin10-20 ug/mL Methoxatin?