from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0560c/-

LFCtreatmentdescriptionclass of inhibitor

-0.522

Amikacinug/mL Amikacintranslation

-0.518

Cap5-10ug/mL Capreomycintranslation

-0.276

Rox10-50 ug/mL Roxithromycintranslation

-0.303

SM2-5 ug/mL Streptomycintranslation

-0.513

Tet5-10 ug/mL Tetracyclinetranslation

-0.318

Rif0.2-5ug/mL Rifampicintranscription

-0.379

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.670

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

3.402

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.616

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.455

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.716

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.594

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

3.240

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.298

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.761

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.260

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.224

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.666

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

2.666

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.709

KCN5-20 ug/mL Potassium cyaniderespiration

-0.593

NaN30.2-2 mM Sodium aziderespiration

-0.635

Nigericin50 uM Nigericinrespiration

-0.091

TRC10-150 ug/mL Triclosanrespiration

0.995

TRZ10-25 ug/mL Thioridazinerespiration

2.126

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

2.480

menadione6-10 ug/mL Menadionerespiration

-0.124

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.574

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.463

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.498

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.541

NRP_1Non-replicating persistence stage 1dosRassociated

-0.656

Amp0.2mg/mL AmpicillincellWall

-0.474

Cephalexin20-100 ug/mL CephalexincellWall

-0.590

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.411

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.812

EMB10-20 ug/mL EthambutolcellWall

-0.846

Eta12-40 ug/mL EthionamidecellWall

-0.579

INH0.2-0.4 ug/mL IsoniazidcellWall

1.584

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.102

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.365

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.849

BZA0.12 mg/mL BenzamidearomaticAmides

1.081

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.198

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.554

H2O24 mM hydrogen peroxideDNAdamaging

-0.389

Levo10 ug/mL LevofloxacinDNAdamaging

-0.435

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.079

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.499

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.403

UVUV-irradiationDNAdamaging

-0.821

ARP41-4 ug/mL Antitubercular compound ARP4?

0.320

Antimycin12.5-50 ug/mL Antimycin A?

-0.260

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

2.616

PA_110-50 ug/mL Antitubercular compound PA-1?

1.493

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.595

PA8240.2-2 ug/mL PA-824?

-0.255

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.544

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.424

Verapamil50 uM Verapamil?

-0.573

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.789

methoxatin10-20 ug/mL Methoxatin?