from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0547c/-

LFCtreatmentdescriptionclass of inhibitor

1.031

Amikacinug/mL Amikacintranslation

0.180

Cap5-10ug/mL Capreomycintranslation

0.111

Rox10-50 ug/mL Roxithromycintranslation

-0.094

SM2-5 ug/mL Streptomycintranslation

0.357

Tet5-10 ug/mL Tetracyclinetranslation

0.901

Rif0.2-5ug/mL Rifampicintranscription

0.577

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.034

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.208

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.219

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.197

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.835

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.161

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.274

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.343

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.220

Nigericin50 uM Nigericinrespiration

-0.323

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.104

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.774

menadione6-10 ug/mL Menadionerespiration

-1.016

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.071

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.214

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.094

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.097

NRP_1Non-replicating persistence stage 1dosRassociated

0.347

Amp0.2mg/mL AmpicillincellWall

0.539

Cephalexin20-100 ug/mL CephalexincellWall

0.014

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.504

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.514

EMB10-20 ug/mL EthambutolcellWall

0.462

Eta12-40 ug/mL EthionamidecellWall

1.380

INH0.2-0.4 ug/mL IsoniazidcellWall

0.280

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.457

BZA0.12 mg/mL BenzamidearomaticAmides

0.948

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.877

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.847

H2O24 mM hydrogen peroxideDNAdamaging

0.529

Levo10 ug/mL LevofloxacinDNAdamaging

0.254

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.691

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.175

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.450

Antimycin12.5-50 ug/mL Antimycin A?

0.224

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.067

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.123

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.663

PA8240.2-2 ug/mL PA-824?

0.004

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.024

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.118

Verapamil50 uM Verapamil?

0.768

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.151

methoxatin10-20 ug/mL Methoxatin?