from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0536/galE3

LFCtreatmentdescriptionclass of inhibitor

-0.148

Amikacinug/mL Amikacintranslation

-0.884

Cap5-10ug/mL Capreomycintranslation

0.030

Rox10-50 ug/mL Roxithromycintranslation

-1.206

SM2-5 ug/mL Streptomycintranslation

0.370

Tet5-10 ug/mL Tetracyclinetranslation

0.014

Rif0.2-5ug/mL Rifampicintranscription

-0.077

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.775

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.301

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.442

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.859

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.449

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.075

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.105

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.339

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.241

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.326

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.733

KCN5-20 ug/mL Potassium cyaniderespiration

1.986

NaN30.2-2 mM Sodium aziderespiration

-0.555

Nigericin50 uM Nigericinrespiration

-0.335

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.979

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.401

menadione6-10 ug/mL Menadionerespiration

-0.312

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.624

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.038

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.162

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.348

NRP_1Non-replicating persistence stage 1dosRassociated

-0.295

Amp0.2mg/mL AmpicillincellWall

0.145

Cephalexin20-100 ug/mL CephalexincellWall

-0.691

Cerulenin0.32-5 ug/mL CerulenincellWall

0.078

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.219

EMB10-20 ug/mL EthambutolcellWall

-0.648

Eta12-40 ug/mL EthionamidecellWall

-0.096

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.236

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.675

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.621

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.672

BZA0.12 mg/mL BenzamidearomaticAmides

0.650

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.704

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.428

H2O24 mM hydrogen peroxideDNAdamaging

0.131

Levo10 ug/mL LevofloxacinDNAdamaging

0.330

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-4.626

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.823

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.120

UVUV-irradiationDNAdamaging

-0.708

ARP41-4 ug/mL Antitubercular compound ARP4?

0.092

Antimycin12.5-50 ug/mL Antimycin A?

-0.477

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.302

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.595

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.103

PA8240.2-2 ug/mL PA-824?

-0.280

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.147

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.838

Verapamil50 uM Verapamil?

-1.491

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.595

methoxatin10-20 ug/mL Methoxatin?