from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0464c/-

LFCtreatmentdescriptionclass of inhibitor

-0.757

Amikacinug/mL Amikacintranslation

-1.322

Cap5-10ug/mL Capreomycintranslation

-2.134

Rox10-50 ug/mL Roxithromycintranslation

0.870

SM2-5 ug/mL Streptomycintranslation

-2.507

Tet5-10 ug/mL Tetracyclinetranslation

-0.640

Rif0.2-5ug/mL Rifampicintranscription

-0.017

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.139

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.275

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.529

CPZ10-50 ug/mL Chlorpromazinerespiration

2.324

Clofazimine10-13 ug/mL Clofaziminerespiration

0.384

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.024

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.074

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.579

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.402

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.475

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.856

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.375

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.887

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.914

KCN5-20 ug/mL Potassium cyaniderespiration

-0.130

NaN30.2-2 mM Sodium aziderespiration

-0.367

Nigericin50 uM Nigericinrespiration

-0.725

TRC10-150 ug/mL Triclosanrespiration

-1.019

TRZ10-25 ug/mL Thioridazinerespiration

-0.688

Valinomycin0.5-10 uM Valinomycinrespiration

0.515

ZnSO42 mM ZnSO4respiration

1.367

menadione6-10 ug/mL Menadionerespiration

1.206

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.834

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

1.222

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.573

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.529

NRP_1Non-replicating persistence stage 1dosRassociated

0.476

Amp0.2mg/mL AmpicillincellWall

0.064

Cephalexin20-100 ug/mL CephalexincellWall

0.782

Cerulenin0.32-5 ug/mL CerulenincellWall

0.456

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.155

EMB10-20 ug/mL EthambutolcellWall

0.480

Eta12-40 ug/mL EthionamidecellWall

0.119

INH0.2-0.4 ug/mL IsoniazidcellWall

0.481

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.092

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.331

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.191

BZA0.12 mg/mL BenzamidearomaticAmides

-0.171

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.201

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.067

H2O24 mM hydrogen peroxideDNAdamaging

-0.178

Levo10 ug/mL LevofloxacinDNAdamaging

0.688

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.856

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.374

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.122

UVUV-irradiationDNAdamaging

1.349

ARP41-4 ug/mL Antitubercular compound ARP4?

0.292

Antimycin12.5-50 ug/mL Antimycin A?

0.410

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.457

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.079

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.858

PA8240.2-2 ug/mL PA-824?

0.388

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.062

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.444

Verapamil50 uM Verapamil?

0.709

mercaptoethanol2 mM 2-Mercaptoethanol?

0.516

methoxatin10-20 ug/mL Methoxatin?