from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0420c/-

LFCtreatmentdescriptionclass of inhibitor

0.228

Amikacinug/mL Amikacintranslation

1.231

Cap5-10ug/mL Capreomycintranslation

0.903

Rox10-50 ug/mL Roxithromycintranslation

-0.075

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.545

Rif0.2-5ug/mL Rifampicintranscription

0.311

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.475

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.543

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.277

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.757

Clofazimine10-13 ug/mL Clofaziminerespiration

0.133

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.447

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.463

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.014

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.986

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.285

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.464

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.721

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.123

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.611

KCN5-20 ug/mL Potassium cyaniderespiration

-0.565

NaN30.2-2 mM Sodium aziderespiration

-0.340

Nigericin50 uM Nigericinrespiration

-0.035

TRC10-150 ug/mL Triclosanrespiration

-1.325

TRZ10-25 ug/mL Thioridazinerespiration

2.098

Valinomycin0.5-10 uM Valinomycinrespiration

1.379

ZnSO42 mM ZnSO4respiration

-0.332

menadione6-10 ug/mL Menadionerespiration

-0.123

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.277

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.542

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.446

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.145

NRP_1Non-replicating persistence stage 1dosRassociated

-0.022

Amp0.2mg/mL AmpicillincellWall

-0.333

Cephalexin20-100 ug/mL CephalexincellWall

0.470

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.246

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.211

EMB10-20 ug/mL EthambutolcellWall

0.701

Eta12-40 ug/mL EthionamidecellWall

0.017

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.022

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.768

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.814

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.343

BZA0.12 mg/mL BenzamidearomaticAmides

0.383

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.507

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.587

H2O24 mM hydrogen peroxideDNAdamaging

0.278

Levo10 ug/mL LevofloxacinDNAdamaging

0.421

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.978

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.294

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.564

UVUV-irradiationDNAdamaging

0.487

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.280

Antimycin12.5-50 ug/mL Antimycin A?

-0.349

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.317

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.242

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.092

PA8240.2-2 ug/mL PA-824?

-0.850

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.162

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.751

Verapamil50 uM Verapamil?

-0.305

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.195

methoxatin10-20 ug/mL Methoxatin?