from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0413/mutT3

LFCtreatmentdescriptionclass of inhibitor

-0.714

Amikacinug/mL Amikacintranslation

-1.791

Cap5-10ug/mL Capreomycintranslation

-1.209

Rox10-50 ug/mL Roxithromycintranslation

-0.329

SM2-5 ug/mL Streptomycintranslation

-1.521

Tet5-10 ug/mL Tetracyclinetranslation

0.264

Rif0.2-5ug/mL Rifampicintranscription

-1.107

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.080

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.384

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.396

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.648

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.759

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.562

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.481

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.403

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.089

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.225

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.115

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.627

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.050

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.782

KCN5-20 ug/mL Potassium cyaniderespiration

0.384

NaN30.2-2 mM Sodium aziderespiration

-0.337

Nigericin50 uM Nigericinrespiration

-0.664

TRC10-150 ug/mL Triclosanrespiration

0.171

TRZ10-25 ug/mL Thioridazinerespiration

-1.012

Valinomycin0.5-10 uM Valinomycinrespiration

-0.995

ZnSO42 mM ZnSO4respiration

-0.013

menadione6-10 ug/mL Menadionerespiration

-0.318

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.491

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.025

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.250

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.575

NRP_1Non-replicating persistence stage 1dosRassociated

-0.320

Amp0.2mg/mL AmpicillincellWall

-0.615

Cephalexin20-100 ug/mL CephalexincellWall

-0.321

Cerulenin0.32-5 ug/mL CerulenincellWall

0.657

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.107

EMB10-20 ug/mL EthambutolcellWall

-0.281

Eta12-40 ug/mL EthionamidecellWall

0.114

INH0.2-0.4 ug/mL IsoniazidcellWall

0.301

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.101

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.703

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.530

BZA0.12 mg/mL BenzamidearomaticAmides

0.435

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.762

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.645

H2O24 mM hydrogen peroxideDNAdamaging

-0.467

Levo10 ug/mL LevofloxacinDNAdamaging

0.111

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.776

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.725

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.866

UVUV-irradiationDNAdamaging

2.432

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.113

Antimycin12.5-50 ug/mL Antimycin A?

-0.629

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.232

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.224

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.704

PA8240.2-2 ug/mL PA-824?

0.322

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.251

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.718

Verapamil50 uM Verapamil?

-0.219

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.739

methoxatin10-20 ug/mL Methoxatin?