from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0404/fadD30

LFCtreatmentdescriptionclass of inhibitor

-1.099

Amikacinug/mL Amikacintranslation

-1.359

Cap5-10ug/mL Capreomycintranslation

-3.006

Rox10-50 ug/mL Roxithromycintranslation

-0.999

SM2-5 ug/mL Streptomycintranslation

-1.983

Tet5-10 ug/mL Tetracyclinetranslation

0.823

Rif0.2-5ug/mL Rifampicintranscription

0.785

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.608

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.465

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.205

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.895

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.011

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.078

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.575

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.110

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.080

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.128

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.306

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.303

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.060

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.857

KCN5-20 ug/mL Potassium cyaniderespiration

0.107

NaN30.2-2 mM Sodium aziderespiration

0.515

Nigericin50 uM Nigericinrespiration

-0.708

TRC10-150 ug/mL Triclosanrespiration

-1.149

TRZ10-25 ug/mL Thioridazinerespiration

-0.679

Valinomycin0.5-10 uM Valinomycinrespiration

0.658

ZnSO42 mM ZnSO4respiration

0.007

menadione6-10 ug/mL Menadionerespiration

-0.328

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.572

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.102

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.007

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.921

NRP_1Non-replicating persistence stage 1dosRassociated

0.528

Amp0.2mg/mL AmpicillincellWall

0.405

Cephalexin20-100 ug/mL CephalexincellWall

0.147

Cerulenin0.32-5 ug/mL CerulenincellWall

0.949

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.425

EMB10-20 ug/mL EthambutolcellWall

1.134

Eta12-40 ug/mL EthionamidecellWall

1.397

INH0.2-0.4 ug/mL IsoniazidcellWall

0.134

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.411

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.702

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.192

BZA0.12 mg/mL BenzamidearomaticAmides

-0.034

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.208

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.589

H2O24 mM hydrogen peroxideDNAdamaging

0.509

Levo10 ug/mL LevofloxacinDNAdamaging

0.779

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.418

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.007

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.477

UVUV-irradiationDNAdamaging

-0.723

ARP41-4 ug/mL Antitubercular compound ARP4?

0.543

Antimycin12.5-50 ug/mL Antimycin A?

0.515

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.544

PA_110-50 ug/mL Antitubercular compound PA-1?

0.364

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.875

PA8240.2-2 ug/mL PA-824?

-0.151

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.072

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.052

Verapamil50 uM Verapamil?

0.293

mercaptoethanol2 mM 2-Mercaptoethanol?

0.583

methoxatin10-20 ug/mL Methoxatin?