from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0400c/fadE7

LFCtreatmentdescriptionclass of inhibitor

-0.108

Amikacinug/mL Amikacintranslation

-1.077

Cap5-10ug/mL Capreomycintranslation

-2.533

Rox10-50 ug/mL Roxithromycintranslation

-0.761

SM2-5 ug/mL Streptomycintranslation

-0.739

Tet5-10 ug/mL Tetracyclinetranslation

-0.517

Rif0.2-5ug/mL Rifampicintranscription

-0.508

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.615

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.221

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.154

CPZ10-50 ug/mL Chlorpromazinerespiration

0.533

Clofazimine10-13 ug/mL Clofaziminerespiration

0.208

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.147

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.882

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.227

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.295

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.415

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.374

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.559

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.379

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.375

KCN5-20 ug/mL Potassium cyaniderespiration

0.528

NaN30.2-2 mM Sodium aziderespiration

-0.280

Nigericin50 uM Nigericinrespiration

0.227

TRC10-150 ug/mL Triclosanrespiration

1.252

TRZ10-25 ug/mL Thioridazinerespiration

-1.043

Valinomycin0.5-10 uM Valinomycinrespiration

-0.528

ZnSO42 mM ZnSO4respiration

0.978

menadione6-10 ug/mL Menadionerespiration

0.051

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.245

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.494

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.170

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.141

NRP_1Non-replicating persistence stage 1dosRassociated

-0.609

Amp0.2mg/mL AmpicillincellWall

-0.020

Cephalexin20-100 ug/mL CephalexincellWall

-0.230

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.986

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.358

EMB10-20 ug/mL EthambutolcellWall

-1.037

Eta12-40 ug/mL EthionamidecellWall

-1.385

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.582

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.045

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.449

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.082

BZA0.12 mg/mL BenzamidearomaticAmides

-0.050

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.093

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.216

H2O24 mM hydrogen peroxideDNAdamaging

-0.011

Levo10 ug/mL LevofloxacinDNAdamaging

-0.368

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.991

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.819

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.888

UVUV-irradiationDNAdamaging

1.172

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.354

Antimycin12.5-50 ug/mL Antimycin A?

-0.243

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.179

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.195

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.094

PA8240.2-2 ug/mL PA-824?

0.877

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.644

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.064

Verapamil50 uM Verapamil?

-0.361

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.191

methoxatin10-20 ug/mL Methoxatin?