from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0392c/ndhA

LFCtreatmentdescriptionclass of inhibitor

0.647

Amikacinug/mL Amikacintranslation

1.263

Cap5-10ug/mL Capreomycintranslation

0.544

Rox10-50 ug/mL Roxithromycintranslation

-0.254

SM2-5 ug/mL Streptomycintranslation

-0.937

Tet5-10 ug/mL Tetracyclinetranslation

0.005

Rif0.2-5ug/mL Rifampicintranscription

-0.192

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.215

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.089

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.959

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.555

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.244

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.539

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.030

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.246

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.389

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.403

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.553

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.699

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.156

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.572

KCN5-20 ug/mL Potassium cyaniderespiration

0.261

NaN30.2-2 mM Sodium aziderespiration

0.215

Nigericin50 uM Nigericinrespiration

-0.192

TRC10-150 ug/mL Triclosanrespiration

-0.885

TRZ10-25 ug/mL Thioridazinerespiration

0.697

Valinomycin0.5-10 uM Valinomycinrespiration

-0.757

ZnSO42 mM ZnSO4respiration

2.817

menadione6-10 ug/mL Menadionerespiration

-0.223

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.017

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.132

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.065

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.815

NRP_1Non-replicating persistence stage 1dosRassociated

-0.794

Amp0.2mg/mL AmpicillincellWall

-0.103

Cephalexin20-100 ug/mL CephalexincellWall

0.029

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.659

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.634

EMB10-20 ug/mL EthambutolcellWall

-0.671

Eta12-40 ug/mL EthionamidecellWall

-0.922

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.860

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.182

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.267

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.364

BZA0.12 mg/mL BenzamidearomaticAmides

0.417

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.865

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.423

H2O24 mM hydrogen peroxideDNAdamaging

-0.089

Levo10 ug/mL LevofloxacinDNAdamaging

0.424

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.350

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.352

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.078

UVUV-irradiationDNAdamaging

2.719

ARP41-4 ug/mL Antitubercular compound ARP4?

0.384

Antimycin12.5-50 ug/mL Antimycin A?

-0.045

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.193

PA_110-50 ug/mL Antitubercular compound PA-1?

0.013

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.058

PA8240.2-2 ug/mL PA-824?

-0.271

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.469

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.204

Verapamil50 uM Verapamil?

-0.459

mercaptoethanol2 mM 2-Mercaptoethanol?

0.731

methoxatin10-20 ug/mL Methoxatin?