from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0372c/-

LFCtreatmentdescriptionclass of inhibitor

-0.313

Amikacinug/mL Amikacintranslation

-0.045

Cap5-10ug/mL Capreomycintranslation

0.426

Rox10-50 ug/mL Roxithromycintranslation

-0.641

SM2-5 ug/mL Streptomycintranslation

-0.600

Tet5-10 ug/mL Tetracyclinetranslation

0.933

Rif0.2-5ug/mL Rifampicintranscription

-0.883

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.483

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.302

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.318

CPZ10-50 ug/mL Chlorpromazinerespiration

0.875

Clofazimine10-13 ug/mL Clofaziminerespiration

-1.030

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.737

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.476

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.435

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.982

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.127

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.814

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.607

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.334

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.941

KCN5-20 ug/mL Potassium cyaniderespiration

-0.827

NaN30.2-2 mM Sodium aziderespiration

0.085

Nigericin50 uM Nigericinrespiration

-0.361

TRC10-150 ug/mL Triclosanrespiration

-0.681

TRZ10-25 ug/mL Thioridazinerespiration

0.845

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.083

menadione6-10 ug/mL Menadionerespiration

0.504

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.356

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.737

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.007

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.096

NRP_1Non-replicating persistence stage 1dosRassociated

-0.427

Amp0.2mg/mL AmpicillincellWall

-0.275

Cephalexin20-100 ug/mL CephalexincellWall

-0.028

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.062

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.163

EMB10-20 ug/mL EthambutolcellWall

-1.082

Eta12-40 ug/mL EthionamidecellWall

-0.969

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.691

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.482

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.598

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.074

BZA0.12 mg/mL BenzamidearomaticAmides

0.521

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.155

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.856

H2O24 mM hydrogen peroxideDNAdamaging

1.063

Levo10 ug/mL LevofloxacinDNAdamaging

0.299

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.689

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.494

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.225

UVUV-irradiationDNAdamaging

1.204

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.177

Antimycin12.5-50 ug/mL Antimycin A?

-0.656

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.063

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.821

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.882

PA8240.2-2 ug/mL PA-824?

-0.150

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.006

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.083

Verapamil50 uM Verapamil?

-0.254

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.615

methoxatin10-20 ug/mL Methoxatin?