from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0371c/-

LFCtreatmentdescriptionclass of inhibitor

-0.503

Amikacinug/mL Amikacintranslation

-0.690

Cap5-10ug/mL Capreomycintranslation

-0.090

Rox10-50 ug/mL Roxithromycintranslation

0.444

SM2-5 ug/mL Streptomycintranslation

-0.868

Tet5-10 ug/mL Tetracyclinetranslation

0.483

Rif0.2-5ug/mL Rifampicintranscription

-0.238

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.030

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.542

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.950

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.877

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.000

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.500

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.622

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.076

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.474

Nigericin50 uM Nigericinrespiration

-0.107

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.117

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.101

menadione6-10 ug/mL Menadionerespiration

-0.245

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.614

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.602

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.773

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.567

NRP_1Non-replicating persistence stage 1dosRassociated

-0.613

Amp0.2mg/mL AmpicillincellWall

0.113

Cephalexin20-100 ug/mL CephalexincellWall

-0.706

Cerulenin0.32-5 ug/mL CerulenincellWall

1.746

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.285

EMB10-20 ug/mL EthambutolcellWall

-0.604

Eta12-40 ug/mL EthionamidecellWall

-0.629

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.586

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.278

BZA0.12 mg/mL BenzamidearomaticAmides

0.020

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.034

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.265

H2O24 mM hydrogen peroxideDNAdamaging

-0.536

Levo10 ug/mL LevofloxacinDNAdamaging

0.311

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.573

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.039

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

1.950

Antimycin12.5-50 ug/mL Antimycin A?

0.396

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.861

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.042

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.184

PA8240.2-2 ug/mL PA-824?

0.142

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.149

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.120

Verapamil50 uM Verapamil?

0.486

mercaptoethanol2 mM 2-Mercaptoethanol?

1.756

methoxatin10-20 ug/mL Methoxatin?