from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0362/mgtE

LFCtreatmentdescriptionclass of inhibitor

0.361

Amikacinug/mL Amikacintranslation

0.733

Cap5-10ug/mL Capreomycintranslation

0.488

Rox10-50 ug/mL Roxithromycintranslation

0.218

SM2-5 ug/mL Streptomycintranslation

-1.900

Tet5-10 ug/mL Tetracyclinetranslation

0.592

Rif0.2-5ug/mL Rifampicintranscription

0.005

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.595

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.776

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.126

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.625

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.354

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.377

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.488

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.140

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.948

NaN30.2-2 mM Sodium aziderespiration

-2.293

Nigericin50 uM Nigericinrespiration

-0.067

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-1.317

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.055

menadione6-10 ug/mL Menadionerespiration

0.143

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.677

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.415

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.581

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.139

NRP_1Non-replicating persistence stage 1dosRassociated

-0.370

Amp0.2mg/mL AmpicillincellWall

0.326

Cephalexin20-100 ug/mL CephalexincellWall

-0.308

Cerulenin0.32-5 ug/mL CerulenincellWall

0.228

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.250

EMB10-20 ug/mL EthambutolcellWall

-1.431

Eta12-40 ug/mL EthionamidecellWall

-1.401

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.385

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.716

BZA0.12 mg/mL BenzamidearomaticAmides

0.905

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.386

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.420

H2O24 mM hydrogen peroxideDNAdamaging

0.058

Levo10 ug/mL LevofloxacinDNAdamaging

0.832

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.188

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.453

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.493

Antimycin12.5-50 ug/mL Antimycin A?

-1.133

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.163

PA_110-50 ug/mL Antitubercular compound PA-1?

0.130

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.638

PA8240.2-2 ug/mL PA-824?

-0.024

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.414

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.519

Verapamil50 uM Verapamil?

-0.329

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.416

methoxatin10-20 ug/mL Methoxatin?