from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0354c/PPE7

LFCtreatmentdescriptionclass of inhibitor

-0.340

Amikacinug/mL Amikacintranslation

0.945

Cap5-10ug/mL Capreomycintranslation

0.159

Rox10-50 ug/mL Roxithromycintranslation

0.044

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.225

Rif0.2-5ug/mL Rifampicintranscription

-0.278

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.919

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.771

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.019

CPZ10-50 ug/mL Chlorpromazinerespiration

1.301

Clofazimine10-13 ug/mL Clofaziminerespiration

0.868

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.424

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.183

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.877

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.918

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.457

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.504

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.642

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.526

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.611

KCN5-20 ug/mL Potassium cyaniderespiration

0.127

NaN30.2-2 mM Sodium aziderespiration

-0.059

Nigericin50 uM Nigericinrespiration

-0.693

TRC10-150 ug/mL Triclosanrespiration

0.038

TRZ10-25 ug/mL Thioridazinerespiration

-1.229

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.007

menadione6-10 ug/mL Menadionerespiration

-0.401

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.745

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.587

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.034

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.061

NRP_1Non-replicating persistence stage 1dosRassociated

-0.387

Amp0.2mg/mL AmpicillincellWall

-0.427

Cephalexin20-100 ug/mL CephalexincellWall

-0.199

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.011

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.194

EMB10-20 ug/mL EthambutolcellWall

-0.470

Eta12-40 ug/mL EthionamidecellWall

-0.845

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.067

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.767

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.937

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.561

BZA0.12 mg/mL BenzamidearomaticAmides

0.886

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.606

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.672

H2O24 mM hydrogen peroxideDNAdamaging

-0.376

Levo10 ug/mL LevofloxacinDNAdamaging

0.144

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.993

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.703

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.087

UVUV-irradiationDNAdamaging

1.298

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.681

Antimycin12.5-50 ug/mL Antimycin A?

0.437

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.032

PA_110-50 ug/mL Antitubercular compound PA-1?

0.007

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.261

PA8240.2-2 ug/mL PA-824?

0.558

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.237

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.944

Verapamil50 uM Verapamil?

0.258

mercaptoethanol2 mM 2-Mercaptoethanol?

0.830

methoxatin10-20 ug/mL Methoxatin?