from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0352/dnaJ1

LFCtreatmentdescriptionclass of inhibitor

0.556

Amikacinug/mL Amikacintranslation

-0.363

Cap5-10ug/mL Capreomycintranslation

-0.909

Rox10-50 ug/mL Roxithromycintranslation

2.150

SM2-5 ug/mL Streptomycintranslation

-1.050

Tet5-10 ug/mL Tetracyclinetranslation

-1.722

Rif0.2-5ug/mL Rifampicintranscription

-1.097

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.355

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.097

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.395

CPZ10-50 ug/mL Chlorpromazinerespiration

0.085

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.224

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.624

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.133

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.487

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.383

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.336

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.872

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.182

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.665

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.608

KCN5-20 ug/mL Potassium cyaniderespiration

-0.092

NaN30.2-2 mM Sodium aziderespiration

-1.046

Nigericin50 uM Nigericinrespiration

0.151

TRC10-150 ug/mL Triclosanrespiration

0.033

TRZ10-25 ug/mL Thioridazinerespiration

1.142

Valinomycin0.5-10 uM Valinomycinrespiration

-1.057

ZnSO42 mM ZnSO4respiration

1.819

menadione6-10 ug/mL Menadionerespiration

-0.304

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.267

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.111

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.153

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.049

NRP_1Non-replicating persistence stage 1dosRassociated

0.451

Amp0.2mg/mL AmpicillincellWall

-0.050

Cephalexin20-100 ug/mL CephalexincellWall

1.028

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.026

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.011

EMB10-20 ug/mL EthambutolcellWall

-0.406

Eta12-40 ug/mL EthionamidecellWall

-0.056

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.440

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.787

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.296

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.334

BZA0.12 mg/mL BenzamidearomaticAmides

1.311

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.457

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.844

H2O24 mM hydrogen peroxideDNAdamaging

0.200

Levo10 ug/mL LevofloxacinDNAdamaging

0.527

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.069

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.026

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.250

UVUV-irradiationDNAdamaging

2.279

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.184

Antimycin12.5-50 ug/mL Antimycin A?

-0.082

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.112

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.139

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.888

PA8240.2-2 ug/mL PA-824?

0.086

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.653

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.716

Verapamil50 uM Verapamil?

-0.466

mercaptoethanol2 mM 2-Mercaptoethanol?

0.337

methoxatin10-20 ug/mL Methoxatin?