from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0344c/lpqJ

LFCtreatmentdescriptionclass of inhibitor

-0.492

Amikacinug/mL Amikacintranslation

0.718

Cap5-10ug/mL Capreomycintranslation

1.084

Rox10-50 ug/mL Roxithromycintranslation

-0.155

SM2-5 ug/mL Streptomycintranslation

0.803

Tet5-10 ug/mL Tetracyclinetranslation

0.692

Rif0.2-5ug/mL Rifampicintranscription

-0.350

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.070

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.218

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.256

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.376

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.659

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.005

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.612

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.771

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.051

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.686

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.022

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.819

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.189

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.031

KCN5-20 ug/mL Potassium cyaniderespiration

-0.470

NaN30.2-2 mM Sodium aziderespiration

0.354

Nigericin50 uM Nigericinrespiration

-0.132

TRC10-150 ug/mL Triclosanrespiration

-1.035

TRZ10-25 ug/mL Thioridazinerespiration

-1.576

Valinomycin0.5-10 uM Valinomycinrespiration

1.198

ZnSO42 mM ZnSO4respiration

0.003

menadione6-10 ug/mL Menadionerespiration

-0.311

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.254

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.665

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.300

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.865

NRP_1Non-replicating persistence stage 1dosRassociated

0.206

Amp0.2mg/mL AmpicillincellWall

0.716

Cephalexin20-100 ug/mL CephalexincellWall

0.161

Cerulenin0.32-5 ug/mL CerulenincellWall

0.843

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.406

EMB10-20 ug/mL EthambutolcellWall

-0.250

Eta12-40 ug/mL EthionamidecellWall

-0.689

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.079

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.589

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.575

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.828

BZA0.12 mg/mL BenzamidearomaticAmides

0.762

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.284

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.763

H2O24 mM hydrogen peroxideDNAdamaging

-0.002

Levo10 ug/mL LevofloxacinDNAdamaging

0.700

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.362

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.142

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.542

UVUV-irradiationDNAdamaging

-1.867

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.107

Antimycin12.5-50 ug/mL Antimycin A?

0.776

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.167

PA_110-50 ug/mL Antitubercular compound PA-1?

0.311

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.083

PA8240.2-2 ug/mL PA-824?

-0.366

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.558

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.289

Verapamil50 uM Verapamil?

-0.024

mercaptoethanol2 mM 2-Mercaptoethanol?

0.883

methoxatin10-20 ug/mL Methoxatin?