from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0342/iniA

LFCtreatmentdescriptionclass of inhibitor

-0.772

Amikacinug/mL Amikacintranslation

-0.503

Cap5-10ug/mL Capreomycintranslation

-0.352

Rox10-50 ug/mL Roxithromycintranslation

-0.522

SM2-5 ug/mL Streptomycintranslation

-0.707

Tet5-10 ug/mL Tetracyclinetranslation

-0.602

Rif0.2-5ug/mL Rifampicintranscription

-0.808

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.146

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.317

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.056

CPZ10-50 ug/mL Chlorpromazinerespiration

0.556

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.475

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

3.876

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.970

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.324

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.394

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.228

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.213

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.733

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.614

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.988

KCN5-20 ug/mL Potassium cyaniderespiration

-0.697

NaN30.2-2 mM Sodium aziderespiration

-0.268

Nigericin50 uM Nigericinrespiration

-0.058

TRC10-150 ug/mL Triclosanrespiration

0.891

TRZ10-25 ug/mL Thioridazinerespiration

1.342

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.794

menadione6-10 ug/mL Menadionerespiration

-0.445

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.934

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.704

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.472

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.059

NRP_1Non-replicating persistence stage 1dosRassociated

-0.397

Amp0.2mg/mL AmpicillincellWall

-0.312

Cephalexin20-100 ug/mL CephalexincellWall

1.062

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.597

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.586

EMB10-20 ug/mL EthambutolcellWall

1.732

Eta12-40 ug/mL EthionamidecellWall

0.969

INH0.2-0.4 ug/mL IsoniazidcellWall

1.917

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.597

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.856

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.401

BZA0.12 mg/mL BenzamidearomaticAmides

0.214

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.003

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.261

H2O24 mM hydrogen peroxideDNAdamaging

-0.836

Levo10 ug/mL LevofloxacinDNAdamaging

-0.230

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.346

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.758

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.346

UVUV-irradiationDNAdamaging

-0.559

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.759

Antimycin12.5-50 ug/mL Antimycin A?

-0.514

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.565

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.739

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.893

PA8240.2-2 ug/mL PA-824?

0.648

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.285

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.477

Verapamil50 uM Verapamil?

-0.859

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.223

methoxatin10-20 ug/mL Methoxatin?