from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0338c/-

LFCtreatmentdescriptionclass of inhibitor

1.183

Amikacinug/mL Amikacintranslation

1.826

Cap5-10ug/mL Capreomycintranslation

1.942

Rox10-50 ug/mL Roxithromycintranslation

0.452

SM2-5 ug/mL Streptomycintranslation

0.454

Tet5-10 ug/mL Tetracyclinetranslation

-1.148

Rif0.2-5ug/mL Rifampicintranscription

-1.314

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.081

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.048

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.484

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.000

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.165

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.197

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.000

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.614

Nigericin50 uM Nigericinrespiration

-0.961

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.934

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.000

menadione6-10 ug/mL Menadionerespiration

-1.646

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.718

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-1.448

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.000

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.000

NRP_1Non-replicating persistence stage 1dosRassociated

0.296

Amp0.2mg/mL AmpicillincellWall

-0.030

Cephalexin20-100 ug/mL CephalexincellWall

0.631

Cerulenin0.32-5 ug/mL CerulenincellWall

0.273

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.173

EMB10-20 ug/mL EthambutolcellWall

-0.311

Eta12-40 ug/mL EthionamidecellWall

-0.374

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.129

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.035

BZA0.12 mg/mL BenzamidearomaticAmides

0.967

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.104

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.275

H2O24 mM hydrogen peroxideDNAdamaging

0.617

Levo10 ug/mL LevofloxacinDNAdamaging

0.632

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.568

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.677

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.566

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.164

Antimycin12.5-50 ug/mL Antimycin A?

0.832

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.479

PA_110-50 ug/mL Antitubercular compound PA-1?

0.637

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.067

PA8240.2-2 ug/mL PA-824?

-0.745

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.525

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

0.000

mercaptoethanol2 mM 2-Mercaptoethanol?

1.665

methoxatin10-20 ug/mL Methoxatin?