from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0298/-

LFCtreatmentdescriptionclass of inhibitor

0.743

Amikacinug/mL Amikacintranslation

1.476

Cap5-10ug/mL Capreomycintranslation

-0.571

Rox10-50 ug/mL Roxithromycintranslation

0.707

SM2-5 ug/mL Streptomycintranslation

-0.114

Tet5-10 ug/mL Tetracyclinetranslation

-1.149

Rif0.2-5ug/mL Rifampicintranscription

-2.216

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.793

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.272

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.031

CPZ10-50 ug/mL Chlorpromazinerespiration

1.541

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.468

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.928

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.961

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.234

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.001

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.368

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.561

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.286

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.780

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.829

KCN5-20 ug/mL Potassium cyaniderespiration

-0.540

NaN30.2-2 mM Sodium aziderespiration

0.276

Nigericin50 uM Nigericinrespiration

0.026

TRC10-150 ug/mL Triclosanrespiration

0.991

TRZ10-25 ug/mL Thioridazinerespiration

0.170

Valinomycin0.5-10 uM Valinomycinrespiration

-0.771

ZnSO42 mM ZnSO4respiration

0.838

menadione6-10 ug/mL Menadionerespiration

-0.205

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.232

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.365

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.559

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.991

NRP_1Non-replicating persistence stage 1dosRassociated

0.343

Amp0.2mg/mL AmpicillincellWall

0.930

Cephalexin20-100 ug/mL CephalexincellWall

0.429

Cerulenin0.32-5 ug/mL CerulenincellWall

0.568

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.734

EMB10-20 ug/mL EthambutolcellWall

0.699

Eta12-40 ug/mL EthionamidecellWall

1.122

INH0.2-0.4 ug/mL IsoniazidcellWall

0.195

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.311

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.632

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.031

BZA0.12 mg/mL BenzamidearomaticAmides

-0.080

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.197

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.825

H2O24 mM hydrogen peroxideDNAdamaging

-0.625

Levo10 ug/mL LevofloxacinDNAdamaging

0.341

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.903

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.072

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.471

UVUV-irradiationDNAdamaging

-0.329

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.458

Antimycin12.5-50 ug/mL Antimycin A?

-0.543

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.178

PA_110-50 ug/mL Antitubercular compound PA-1?

0.125

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.535

PA8240.2-2 ug/mL PA-824?

0.278

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.743

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.391

Verapamil50 uM Verapamil?

-0.052

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.903

methoxatin10-20 ug/mL Methoxatin?