from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0292/eccE3

LFCtreatmentdescriptionclass of inhibitor

-1.016

Amikacinug/mL Amikacintranslation

-2.404

Cap5-10ug/mL Capreomycintranslation

-1.757

Rox10-50 ug/mL Roxithromycintranslation

-1.603

SM2-5 ug/mL Streptomycintranslation

-2.390

Tet5-10 ug/mL Tetracyclinetranslation

0.203

Rif0.2-5ug/mL Rifampicintranscription

-0.456

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.090

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.208

CPZ10-50 ug/mL Chlorpromazinerespiration

-2.360

Clofazimine10-13 ug/mL Clofaziminerespiration

0.000

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.115

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.556

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.386

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.272

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.432

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.138

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.076

KCN5-20 ug/mL Potassium cyaniderespiration

1.297

NaN30.2-2 mM Sodium aziderespiration

-0.681

Nigericin50 uM Nigericinrespiration

-0.005

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.384

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.696

menadione6-10 ug/mL Menadionerespiration

2.278

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

1.495

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

2.009

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.865

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.315

NRP_1Non-replicating persistence stage 1dosRassociated

-0.061

Amp0.2mg/mL AmpicillincellWall

0.039

Cephalexin20-100 ug/mL CephalexincellWall

0.600

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.087

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.145

EMB10-20 ug/mL EthambutolcellWall

0.132

Eta12-40 ug/mL EthionamidecellWall

0.235

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.088

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.188

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.003

BZA0.12 mg/mL BenzamidearomaticAmides

-0.219

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.088

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.019

H2O24 mM hydrogen peroxideDNAdamaging

-0.449

Levo10 ug/mL LevofloxacinDNAdamaging

0.078

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-1.148

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.015

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.484

Antimycin12.5-50 ug/mL Antimycin A?

-0.909

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.715

PA_110-50 ug/mL Antitubercular compound PA-1?

0.684

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.478

PA8240.2-2 ug/mL PA-824?

-0.899

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.649

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.091

Verapamil50 uM Verapamil?

-0.796

mercaptoethanol2 mM 2-Mercaptoethanol?

0.609

methoxatin10-20 ug/mL Methoxatin?