from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0285/PE5

LFCtreatmentdescriptionclass of inhibitor

-1.004

Amikacinug/mL Amikacintranslation

-1.569

Cap5-10ug/mL Capreomycintranslation

-2.086

Rox10-50 ug/mL Roxithromycintranslation

-0.762

SM2-5 ug/mL Streptomycintranslation

-1.635

Tet5-10 ug/mL Tetracyclinetranslation

0.290

Rif0.2-5ug/mL Rifampicintranscription

-0.433

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.477

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.051

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.381

CPZ10-50 ug/mL Chlorpromazinerespiration

3.113

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.245

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.022

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.102

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.912

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.249

Econazole10-24 ug/mL Econazole (azole drug)respiration

2.468

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.446

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.715

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.308

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.196

KCN5-20 ug/mL Potassium cyaniderespiration

-0.324

NaN30.2-2 mM Sodium aziderespiration

-0.599

Nigericin50 uM Nigericinrespiration

-0.121

TRC10-150 ug/mL Triclosanrespiration

0.228

TRZ10-25 ug/mL Thioridazinerespiration

-0.619

Valinomycin0.5-10 uM Valinomycinrespiration

-1.376

ZnSO42 mM ZnSO4respiration

-1.181

menadione6-10 ug/mL Menadionerespiration

2.189

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

1.065

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

2.034

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.276

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.565

NRP_1Non-replicating persistence stage 1dosRassociated

0.130

Amp0.2mg/mL AmpicillincellWall

0.338

Cephalexin20-100 ug/mL CephalexincellWall

0.104

Cerulenin0.32-5 ug/mL CerulenincellWall

0.087

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.419

EMB10-20 ug/mL EthambutolcellWall

0.773

Eta12-40 ug/mL EthionamidecellWall

1.079

INH0.2-0.4 ug/mL IsoniazidcellWall

0.533

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.361

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.110

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.042

BZA0.12 mg/mL BenzamidearomaticAmides

-0.076

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.119

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.261

H2O24 mM hydrogen peroxideDNAdamaging

-0.258

Levo10 ug/mL LevofloxacinDNAdamaging

-0.108

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

2.352

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.007

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.191

UVUV-irradiationDNAdamaging

0.811

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.139

Antimycin12.5-50 ug/mL Antimycin A?

0.042

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.029

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.136

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.305

PA8240.2-2 ug/mL PA-824?

-0.585

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.352

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.042

Verapamil50 uM Verapamil?

0.293

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.668

methoxatin10-20 ug/mL Methoxatin?