from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0264c/-

LFCtreatmentdescriptionclass of inhibitor

2.258

Amikacinug/mL Amikacintranslation

2.990

Cap5-10ug/mL Capreomycintranslation

3.103

Rox10-50 ug/mL Roxithromycintranslation

0.557

SM2-5 ug/mL Streptomycintranslation

2.294

Tet5-10 ug/mL Tetracyclinetranslation

-0.405

Rif0.2-5ug/mL Rifampicintranscription

-0.418

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.402

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.523

CPZ10-50 ug/mL Chlorpromazinerespiration

0.278

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.363

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.407

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.623

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.097

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.074

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.066

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.657

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.510

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.720

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.222

KCN5-20 ug/mL Potassium cyaniderespiration

-0.558

NaN30.2-2 mM Sodium aziderespiration

1.261

Nigericin50 uM Nigericinrespiration

0.138

TRC10-150 ug/mL Triclosanrespiration

-0.059

TRZ10-25 ug/mL Thioridazinerespiration

0.056

Valinomycin0.5-10 uM Valinomycinrespiration

0.071

ZnSO42 mM ZnSO4respiration

-0.459

menadione6-10 ug/mL Menadionerespiration

0.162

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.314

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.427

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.125

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.125

NRP_1Non-replicating persistence stage 1dosRassociated

-0.144

Amp0.2mg/mL AmpicillincellWall

-0.123

Cephalexin20-100 ug/mL CephalexincellWall

-0.799

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.478

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.308

EMB10-20 ug/mL EthambutolcellWall

-0.300

Eta12-40 ug/mL EthionamidecellWall

-0.409

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.581

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.284

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.258

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.419

BZA0.12 mg/mL BenzamidearomaticAmides

-0.406

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.455

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.265

H2O24 mM hydrogen peroxideDNAdamaging

0.145

Levo10 ug/mL LevofloxacinDNAdamaging

-0.332

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.637

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.176

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.018

UVUV-irradiationDNAdamaging

-0.503

ARP41-4 ug/mL Antitubercular compound ARP4?

0.467

Antimycin12.5-50 ug/mL Antimycin A?

-0.172

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.572

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.801

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.488

PA8240.2-2 ug/mL PA-824?

-0.428

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.086

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.228

Verapamil50 uM Verapamil?

-0.339

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.007

methoxatin10-20 ug/mL Methoxatin?