from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0244c/fadE5

LFCtreatmentdescriptionclass of inhibitor

-0.369

Amikacinug/mL Amikacintranslation

-0.740

Cap5-10ug/mL Capreomycintranslation

0.745

Rox10-50 ug/mL Roxithromycintranslation

-0.248

SM2-5 ug/mL Streptomycintranslation

-0.227

Tet5-10 ug/mL Tetracyclinetranslation

-0.328

Rif0.2-5ug/mL Rifampicintranscription

-0.417

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.166

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.426

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.410

CPZ10-50 ug/mL Chlorpromazinerespiration

0.303

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.085

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.071

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.432

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.542

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.052

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.165

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.558

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.970

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.238

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.064

KCN5-20 ug/mL Potassium cyaniderespiration

0.540

NaN30.2-2 mM Sodium aziderespiration

0.092

Nigericin50 uM Nigericinrespiration

0.909

TRC10-150 ug/mL Triclosanrespiration

-0.439

TRZ10-25 ug/mL Thioridazinerespiration

0.526

Valinomycin0.5-10 uM Valinomycinrespiration

-0.307

ZnSO42 mM ZnSO4respiration

-0.205

menadione6-10 ug/mL Menadionerespiration

-0.200

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.637

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.282

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.711

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.238

NRP_1Non-replicating persistence stage 1dosRassociated

-0.372

Amp0.2mg/mL AmpicillincellWall

-0.173

Cephalexin20-100 ug/mL CephalexincellWall

-1.061

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.438

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.381

EMB10-20 ug/mL EthambutolcellWall

0.855

Eta12-40 ug/mL EthionamidecellWall

1.047

INH0.2-0.4 ug/mL IsoniazidcellWall

0.909

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-2.125

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-2.016

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.076

BZA0.12 mg/mL BenzamidearomaticAmides

0.718

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.164

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.408

H2O24 mM hydrogen peroxideDNAdamaging

-0.778

Levo10 ug/mL LevofloxacinDNAdamaging

-0.268

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.989

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.453

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.149

UVUV-irradiationDNAdamaging

-0.715

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.206

Antimycin12.5-50 ug/mL Antimycin A?

-0.784

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.324

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.311

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.134

PA8240.2-2 ug/mL PA-824?

2.331

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.343

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.781

Verapamil50 uM Verapamil?

-0.597

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.189

methoxatin10-20 ug/mL Methoxatin?