from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0235c/-

LFCtreatmentdescriptionclass of inhibitor

0.085

Amikacinug/mL Amikacintranslation

-0.005

Cap5-10ug/mL Capreomycintranslation

-0.708

Rox10-50 ug/mL Roxithromycintranslation

-0.197

SM2-5 ug/mL Streptomycintranslation

-2.056

Tet5-10 ug/mL Tetracyclinetranslation

0.361

Rif0.2-5ug/mL Rifampicintranscription

-0.262

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.663

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.006

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.191

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.034

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.280

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.308

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.510

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.263

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.948

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.012

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.918

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.014

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.138

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.106

KCN5-20 ug/mL Potassium cyaniderespiration

-1.449

NaN30.2-2 mM Sodium aziderespiration

-0.076

Nigericin50 uM Nigericinrespiration

0.873

TRC10-150 ug/mL Triclosanrespiration

0.305

TRZ10-25 ug/mL Thioridazinerespiration

-0.061

Valinomycin0.5-10 uM Valinomycinrespiration

1.762

ZnSO42 mM ZnSO4respiration

0.010

menadione6-10 ug/mL Menadionerespiration

0.444

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.180

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.248

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.144

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.291

NRP_1Non-replicating persistence stage 1dosRassociated

-0.508

Amp0.2mg/mL AmpicillincellWall

-0.247

Cephalexin20-100 ug/mL CephalexincellWall

1.380

Cerulenin0.32-5 ug/mL CerulenincellWall

0.238

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.030

EMB10-20 ug/mL EthambutolcellWall

-0.601

Eta12-40 ug/mL EthionamidecellWall

-0.055

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.220

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.299

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.407

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.180

BZA0.12 mg/mL BenzamidearomaticAmides

0.073

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.013

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.045

H2O24 mM hydrogen peroxideDNAdamaging

0.090

Levo10 ug/mL LevofloxacinDNAdamaging

-0.239

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.923

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.022

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.175

UVUV-irradiationDNAdamaging

-0.743

ARP41-4 ug/mL Antitubercular compound ARP4?

0.459

Antimycin12.5-50 ug/mL Antimycin A?

0.048

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.596

PA_110-50 ug/mL Antitubercular compound PA-1?

0.571

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.249

PA8240.2-2 ug/mL PA-824?

1.115

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.386

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.624

Verapamil50 uM Verapamil?

-0.230

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.762

methoxatin10-20 ug/mL Methoxatin?