from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0220/lipC

LFCtreatmentdescriptionclass of inhibitor

-0.495

Amikacinug/mL Amikacintranslation

-0.658

Cap5-10ug/mL Capreomycintranslation

-1.483

Rox10-50 ug/mL Roxithromycintranslation

0.147

SM2-5 ug/mL Streptomycintranslation

-0.786

Tet5-10 ug/mL Tetracyclinetranslation

0.720

Rif0.2-5ug/mL Rifampicintranscription

-0.525

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.411

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.777

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.922

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.807

Clofazimine10-13 ug/mL Clofaziminerespiration

0.104

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.304

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.307

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.692

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.660

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.369

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.474

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.295

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.001

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.774

KCN5-20 ug/mL Potassium cyaniderespiration

0.107

NaN30.2-2 mM Sodium aziderespiration

0.659

Nigericin50 uM Nigericinrespiration

-0.480

TRC10-150 ug/mL Triclosanrespiration

-2.058

TRZ10-25 ug/mL Thioridazinerespiration

-2.943

Valinomycin0.5-10 uM Valinomycinrespiration

0.148

ZnSO42 mM ZnSO4respiration

0.192

menadione6-10 ug/mL Menadionerespiration

-0.406

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.113

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.193

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.287

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.654

NRP_1Non-replicating persistence stage 1dosRassociated

0.395

Amp0.2mg/mL AmpicillincellWall

-0.053

Cephalexin20-100 ug/mL CephalexincellWall

0.367

Cerulenin0.32-5 ug/mL CerulenincellWall

0.382

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.557

EMB10-20 ug/mL EthambutolcellWall

0.486

Eta12-40 ug/mL EthionamidecellWall

0.622

INH0.2-0.4 ug/mL IsoniazidcellWall

0.464

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.104

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.287

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.004

BZA0.12 mg/mL BenzamidearomaticAmides

0.092

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.225

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.563

H2O24 mM hydrogen peroxideDNAdamaging

0.250

Levo10 ug/mL LevofloxacinDNAdamaging

0.759

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.456

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.766

Oflox5-10 ug/mL OfloxacinDNAdamaging

1.107

UVUV-irradiationDNAdamaging

-0.263

ARP41-4 ug/mL Antitubercular compound ARP4?

0.729

Antimycin12.5-50 ug/mL Antimycin A?

0.424

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.697

PA_110-50 ug/mL Antitubercular compound PA-1?

0.309

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.122

PA8240.2-2 ug/mL PA-824?

-0.830

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.101

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.080

Verapamil50 uM Verapamil?

0.628

mercaptoethanol2 mM 2-Mercaptoethanol?

0.218

methoxatin10-20 ug/mL Methoxatin?