from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0215c/fadE3

LFCtreatmentdescriptionclass of inhibitor

0.141

Amikacinug/mL Amikacintranslation

0.378

Cap5-10ug/mL Capreomycintranslation

0.755

Rox10-50 ug/mL Roxithromycintranslation

-0.268

SM2-5 ug/mL Streptomycintranslation

0.133

Tet5-10 ug/mL Tetracyclinetranslation

0.543

Rif0.2-5ug/mL Rifampicintranscription

0.156

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.756

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.062

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.307

CPZ10-50 ug/mL Chlorpromazinerespiration

0.735

Clofazimine10-13 ug/mL Clofaziminerespiration

0.264

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.707

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.018

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.296

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.217

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.759

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.015

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.003

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.693

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.333

KCN5-20 ug/mL Potassium cyaniderespiration

0.140

NaN30.2-2 mM Sodium aziderespiration

-0.264

Nigericin50 uM Nigericinrespiration

0.350

TRC10-150 ug/mL Triclosanrespiration

0.902

TRZ10-25 ug/mL Thioridazinerespiration

0.346

Valinomycin0.5-10 uM Valinomycinrespiration

-0.135

ZnSO42 mM ZnSO4respiration

0.342

menadione6-10 ug/mL Menadionerespiration

0.786

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.395

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

1.501

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.226

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.447

NRP_1Non-replicating persistence stage 1dosRassociated

-0.544

Amp0.2mg/mL AmpicillincellWall

-0.335

Cephalexin20-100 ug/mL CephalexincellWall

0.003

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.046

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.361

EMB10-20 ug/mL EthambutolcellWall

-0.416

Eta12-40 ug/mL EthionamidecellWall

-0.625

INH0.2-0.4 ug/mL IsoniazidcellWall

0.080

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.073

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.343

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.207

BZA0.12 mg/mL BenzamidearomaticAmides

-0.701

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-1.060

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.411

H2O24 mM hydrogen peroxideDNAdamaging

0.085

Levo10 ug/mL LevofloxacinDNAdamaging

-0.601

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.391

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.172

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.461

UVUV-irradiationDNAdamaging

1.045

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.013

Antimycin12.5-50 ug/mL Antimycin A?

0.514

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.749

PA_110-50 ug/mL Antitubercular compound PA-1?

0.747

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.061

PA8240.2-2 ug/mL PA-824?

0.333

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.651

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.773

Verapamil50 uM Verapamil?

0.540

mercaptoethanol2 mM 2-Mercaptoethanol?

0.083

methoxatin10-20 ug/mL Methoxatin?