from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0207c/-

LFCtreatmentdescriptionclass of inhibitor

0.121

Amikacinug/mL Amikacintranslation

0.067

Cap5-10ug/mL Capreomycintranslation

-0.211

Rox10-50 ug/mL Roxithromycintranslation

0.047

SM2-5 ug/mL Streptomycintranslation

-0.602

Tet5-10 ug/mL Tetracyclinetranslation

0.918

Rif0.2-5ug/mL Rifampicintranscription

-0.092

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.756

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.243

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.504

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.258

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.617

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.381

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.822

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.255

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.247

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.117

Nigericin50 uM Nigericinrespiration

-0.105

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.090

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.647

menadione6-10 ug/mL Menadionerespiration

-0.075

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.335

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.091

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.567

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.484

NRP_1Non-replicating persistence stage 1dosRassociated

1.066

Amp0.2mg/mL AmpicillincellWall

0.124

Cephalexin20-100 ug/mL CephalexincellWall

1.040

Cerulenin0.32-5 ug/mL CerulenincellWall

0.340

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.472

EMB10-20 ug/mL EthambutolcellWall

1.760

Eta12-40 ug/mL EthionamidecellWall

2.054

INH0.2-0.4 ug/mL IsoniazidcellWall

1.027

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.103

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.570

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.918

BZA0.12 mg/mL BenzamidearomaticAmides

-0.847

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.914

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.159

H2O24 mM hydrogen peroxideDNAdamaging

0.506

Levo10 ug/mL LevofloxacinDNAdamaging

-0.865

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.421

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.109

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.622

Antimycin12.5-50 ug/mL Antimycin A?

-1.485

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.216

PA_110-50 ug/mL Antitubercular compound PA-1?

0.038

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.079

PA8240.2-2 ug/mL PA-824?

0.304

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.158

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

2.600

Verapamil50 uM Verapamil?

-1.016

mercaptoethanol2 mM 2-Mercaptoethanol?

1.995

methoxatin10-20 ug/mL Methoxatin?