from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0205/-

LFCtreatmentdescriptionclass of inhibitor

0.128

Amikacinug/mL Amikacintranslation

0.689

Cap5-10ug/mL Capreomycintranslation

0.740

Rox10-50 ug/mL Roxithromycintranslation

0.414

SM2-5 ug/mL Streptomycintranslation

0.420

Tet5-10 ug/mL Tetracyclinetranslation

1.827

Rif0.2-5ug/mL Rifampicintranscription

0.631

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.449

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.628

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.344

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.312

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.371

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.720

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.447

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.099

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.483

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.551

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.013

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.434

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.642

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.144

KCN5-20 ug/mL Potassium cyaniderespiration

0.921

NaN30.2-2 mM Sodium aziderespiration

-0.426

Nigericin50 uM Nigericinrespiration

-0.168

TRC10-150 ug/mL Triclosanrespiration

-1.228

TRZ10-25 ug/mL Thioridazinerespiration

-1.130

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.462

menadione6-10 ug/mL Menadionerespiration

0.050

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.094

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.594

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.086

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.516

NRP_1Non-replicating persistence stage 1dosRassociated

0.114

Amp0.2mg/mL AmpicillincellWall

0.467

Cephalexin20-100 ug/mL CephalexincellWall

0.236

Cerulenin0.32-5 ug/mL CerulenincellWall

0.518

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.336

EMB10-20 ug/mL EthambutolcellWall

0.417

Eta12-40 ug/mL EthionamidecellWall

0.485

INH0.2-0.4 ug/mL IsoniazidcellWall

0.318

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.738

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.340

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.172

BZA0.12 mg/mL BenzamidearomaticAmides

0.253

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.065

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.208

H2O24 mM hydrogen peroxideDNAdamaging

0.777

Levo10 ug/mL LevofloxacinDNAdamaging

-0.350

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.047

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.812

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.351

UVUV-irradiationDNAdamaging

-0.772

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.712

Antimycin12.5-50 ug/mL Antimycin A?

1.058

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.121

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.111

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.134

PA8240.2-2 ug/mL PA-824?

-0.481

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.053

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.380

Verapamil50 uM Verapamil?

0.666

mercaptoethanol2 mM 2-Mercaptoethanol?

0.170

methoxatin10-20 ug/mL Methoxatin?