from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0204c/-

LFCtreatmentdescriptionclass of inhibitor

-0.291

Amikacinug/mL Amikacintranslation

-0.133

Cap5-10ug/mL Capreomycintranslation

-0.990

Rox10-50 ug/mL Roxithromycintranslation

0.128

SM2-5 ug/mL Streptomycintranslation

-0.333

Tet5-10 ug/mL Tetracyclinetranslation

-1.769

Rif0.2-5ug/mL Rifampicintranscription

-1.078

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.786

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.552

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.169

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.639

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.071

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.657

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.876

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.455

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.197

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.393

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.509

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.963

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.403

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.371

KCN5-20 ug/mL Potassium cyaniderespiration

-0.286

NaN30.2-2 mM Sodium aziderespiration

0.397

Nigericin50 uM Nigericinrespiration

-0.574

TRC10-150 ug/mL Triclosanrespiration

-1.343

TRZ10-25 ug/mL Thioridazinerespiration

-0.658

Valinomycin0.5-10 uM Valinomycinrespiration

-0.410

ZnSO42 mM ZnSO4respiration

0.105

menadione6-10 ug/mL Menadionerespiration

-0.575

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.132

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.322

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.642

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.949

NRP_1Non-replicating persistence stage 1dosRassociated

0.699

Amp0.2mg/mL AmpicillincellWall

-0.233

Cephalexin20-100 ug/mL CephalexincellWall

0.447

Cerulenin0.32-5 ug/mL CerulenincellWall

0.173

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.518

EMB10-20 ug/mL EthambutolcellWall

0.396

Eta12-40 ug/mL EthionamidecellWall

0.422

INH0.2-0.4 ug/mL IsoniazidcellWall

0.327

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.511

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.512

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.113

BZA0.12 mg/mL BenzamidearomaticAmides

-0.324

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.863

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.367

H2O24 mM hydrogen peroxideDNAdamaging

2.163

Levo10 ug/mL LevofloxacinDNAdamaging

0.526

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.957

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.483

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.162

UVUV-irradiationDNAdamaging

-0.775

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.156

Antimycin12.5-50 ug/mL Antimycin A?

0.508

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.269

PA_110-50 ug/mL Antitubercular compound PA-1?

0.333

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.881

PA8240.2-2 ug/mL PA-824?

-0.204

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.475

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.444

Verapamil50 uM Verapamil?

0.364

mercaptoethanol2 mM 2-Mercaptoethanol?

0.314

methoxatin10-20 ug/mL Methoxatin?