from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0203/-

LFCtreatmentdescriptionclass of inhibitor

1.998

Amikacinug/mL Amikacintranslation

1.484

Cap5-10ug/mL Capreomycintranslation

0.639

Rox10-50 ug/mL Roxithromycintranslation

0.957

SM2-5 ug/mL Streptomycintranslation

1.866

Tet5-10 ug/mL Tetracyclinetranslation

-0.349

Rif0.2-5ug/mL Rifampicintranscription

0.178

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.775

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.782

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.132

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.348

Clofazimine10-13 ug/mL Clofaziminerespiration

0.263

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.836

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.020

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.005

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.116

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.247

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.055

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.095

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.132

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.553

KCN5-20 ug/mL Potassium cyaniderespiration

-0.689

NaN30.2-2 mM Sodium aziderespiration

0.875

Nigericin50 uM Nigericinrespiration

-0.824

TRC10-150 ug/mL Triclosanrespiration

-0.910

TRZ10-25 ug/mL Thioridazinerespiration

0.097

Valinomycin0.5-10 uM Valinomycinrespiration

0.206

ZnSO42 mM ZnSO4respiration

0.385

menadione6-10 ug/mL Menadionerespiration

0.202

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.843

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.599

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.691

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.190

NRP_1Non-replicating persistence stage 1dosRassociated

0.351

Amp0.2mg/mL AmpicillincellWall

0.416

Cephalexin20-100 ug/mL CephalexincellWall

0.733

Cerulenin0.32-5 ug/mL CerulenincellWall

0.910

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.554

EMB10-20 ug/mL EthambutolcellWall

0.213

Eta12-40 ug/mL EthionamidecellWall

0.538

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.056

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.510

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.069

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.405

BZA0.12 mg/mL BenzamidearomaticAmides

-0.425

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.118

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.136

H2O24 mM hydrogen peroxideDNAdamaging

0.107

Levo10 ug/mL LevofloxacinDNAdamaging

0.585

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.113

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.551

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.671

UVUV-irradiationDNAdamaging

-1.487

ARP41-4 ug/mL Antitubercular compound ARP4?

0.710

Antimycin12.5-50 ug/mL Antimycin A?

0.813

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.854

PA_110-50 ug/mL Antitubercular compound PA-1?

0.678

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.165

PA8240.2-2 ug/mL PA-824?

-1.230

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.090

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.524

Verapamil50 uM Verapamil?

0.551

mercaptoethanol2 mM 2-Mercaptoethanol?

0.958

methoxatin10-20 ug/mL Methoxatin?