from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0174/mce1F

LFCtreatmentdescriptionclass of inhibitor

-2.012

Amikacinug/mL Amikacintranslation

-1.803

Cap5-10ug/mL Capreomycintranslation

-1.927

Rox10-50 ug/mL Roxithromycintranslation

-1.516

SM2-5 ug/mL Streptomycintranslation

-2.615

Tet5-10 ug/mL Tetracyclinetranslation

-0.404

Rif0.2-5ug/mL Rifampicintranscription

-0.255

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.184

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.116

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.631

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.363

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.468

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.261

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.142

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.176

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.048

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

-0.169

NaN30.2-2 mM Sodium aziderespiration

-0.533

Nigericin50 uM Nigericinrespiration

-1.052

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.092

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.565

menadione6-10 ug/mL Menadionerespiration

-0.555

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.855

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.157

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.040

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.425

NRP_1Non-replicating persistence stage 1dosRassociated

0.651

Amp0.2mg/mL AmpicillincellWall

0.590

Cephalexin20-100 ug/mL CephalexincellWall

-0.045

Cerulenin0.32-5 ug/mL CerulenincellWall

0.554

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.017

EMB10-20 ug/mL EthambutolcellWall

-0.501

Eta12-40 ug/mL EthionamidecellWall

-0.068

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.579

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.251

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.771

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.543

BZA0.12 mg/mL BenzamidearomaticAmides

1.041

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.031

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.374

H2O24 mM hydrogen peroxideDNAdamaging

-0.708

Levo10 ug/mL LevofloxacinDNAdamaging

0.604

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-1.342

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.470

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.786

Antimycin12.5-50 ug/mL Antimycin A?

0.020

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.535

PA_110-50 ug/mL Antitubercular compound PA-1?

1.329

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.917

PA8240.2-2 ug/mL PA-824?

-2.095

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.058

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.112

Verapamil50 uM Verapamil?

0.856

mercaptoethanol2 mM 2-Mercaptoethanol?

0.146

methoxatin10-20 ug/mL Methoxatin?