from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0154c/fadE2

LFCtreatmentdescriptionclass of inhibitor

-0.551

Amikacinug/mL Amikacintranslation

0.635

Cap5-10ug/mL Capreomycintranslation

0.318

Rox10-50 ug/mL Roxithromycintranslation

-0.274

SM2-5 ug/mL Streptomycintranslation

-0.639

Tet5-10 ug/mL Tetracyclinetranslation

-1.436

Rif0.2-5ug/mL Rifampicintranscription

-0.846

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.084

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.569

CPZ10-50 ug/mL Chlorpromazinerespiration

-2.459

Clofazimine10-13 ug/mL Clofaziminerespiration

1.257

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.151

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.190

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.453

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.106

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.000

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-2.120

Nigericin50 uM Nigericinrespiration

-0.049

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.023

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.687

menadione6-10 ug/mL Menadionerespiration

0.757

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.158

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.047

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.911

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.875

NRP_1Non-replicating persistence stage 1dosRassociated

-0.786

Amp0.2mg/mL AmpicillincellWall

0.744

Cephalexin20-100 ug/mL CephalexincellWall

0.584

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.718

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.586

EMB10-20 ug/mL EthambutolcellWall

0.029

Eta12-40 ug/mL EthionamidecellWall

-0.619

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.012

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.404

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.217

BZA0.12 mg/mL BenzamidearomaticAmides

0.251

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.201

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.345

H2O24 mM hydrogen peroxideDNAdamaging

0.909

Levo10 ug/mL LevofloxacinDNAdamaging

0.362

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.586

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.180

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.744

UVUV-irradiationDNAdamaging

0.229

ARP41-4 ug/mL Antitubercular compound ARP4?

0.700

Antimycin12.5-50 ug/mL Antimycin A?

-1.498

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.419

PA_110-50 ug/mL Antitubercular compound PA-1?

0.536

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.400

PA8240.2-2 ug/mL PA-824?

0.685

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.039

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.934

Verapamil50 uM Verapamil?

-2.570

mercaptoethanol2 mM 2-Mercaptoethanol?

0.211

methoxatin10-20 ug/mL Methoxatin?