from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0151c/PE1

LFCtreatmentdescriptionclass of inhibitor

0.446

Amikacinug/mL Amikacintranslation

0.542

Cap5-10ug/mL Capreomycintranslation

0.910

Rox10-50 ug/mL Roxithromycintranslation

0.244

SM2-5 ug/mL Streptomycintranslation

0.971

Tet5-10 ug/mL Tetracyclinetranslation

0.774

Rif0.2-5ug/mL Rifampicintranscription

0.249

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.778

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.495

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.363

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.734

Clofazimine10-13 ug/mL Clofaziminerespiration

0.068

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.803

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.666

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.109

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.074

Econazole10-24 ug/mL Econazole (azole drug)respiration

-2.283

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.350

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.701

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.453

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.316

KCN5-20 ug/mL Potassium cyaniderespiration

-0.408

NaN30.2-2 mM Sodium aziderespiration

-0.409

Nigericin50 uM Nigericinrespiration

-0.438

TRC10-150 ug/mL Triclosanrespiration

-1.579

TRZ10-25 ug/mL Thioridazinerespiration

1.064

Valinomycin0.5-10 uM Valinomycinrespiration

1.714

ZnSO42 mM ZnSO4respiration

-0.862

menadione6-10 ug/mL Menadionerespiration

-0.011

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.379

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.054

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.335

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.686

NRP_1Non-replicating persistence stage 1dosRassociated

-0.263

Amp0.2mg/mL AmpicillincellWall

-0.086

Cephalexin20-100 ug/mL CephalexincellWall

0.499

Cerulenin0.32-5 ug/mL CerulenincellWall

0.093

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.134

EMB10-20 ug/mL EthambutolcellWall

0.654

Eta12-40 ug/mL EthionamidecellWall

0.151

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.074

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.537

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.953

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.115

BZA0.12 mg/mL BenzamidearomaticAmides

0.531

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.219

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.436

H2O24 mM hydrogen peroxideDNAdamaging

0.075

Levo10 ug/mL LevofloxacinDNAdamaging

0.437

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.704

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.014

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.479

UVUV-irradiationDNAdamaging

-2.037

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.461

Antimycin12.5-50 ug/mL Antimycin A?

0.046

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.051

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.076

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.590

PA8240.2-2 ug/mL PA-824?

-0.644

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.259

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.365

Verapamil50 uM Verapamil?

-0.457

mercaptoethanol2 mM 2-Mercaptoethanol?

0.195

methoxatin10-20 ug/mL Methoxatin?