from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0147/-

LFCtreatmentdescriptionclass of inhibitor

0.448

Amikacinug/mL Amikacintranslation

-0.309

Cap5-10ug/mL Capreomycintranslation

-1.153

Rox10-50 ug/mL Roxithromycintranslation

0.313

SM2-5 ug/mL Streptomycintranslation

-1.006

Tet5-10 ug/mL Tetracyclinetranslation

0.317

Rif0.2-5ug/mL Rifampicintranscription

-0.175

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.798

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.660

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.046

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.512

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.226

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.782

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.835

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.407

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.610

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

-0.767

NaN30.2-2 mM Sodium aziderespiration

-0.905

Nigericin50 uM Nigericinrespiration

0.864

TRC10-150 ug/mL Triclosanrespiration

0.009

TRZ10-25 ug/mL Thioridazinerespiration

-0.029

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

1.017

menadione6-10 ug/mL Menadionerespiration

0.056

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.581

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.152

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.181

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.613

NRP_1Non-replicating persistence stage 1dosRassociated

-0.580

Amp0.2mg/mL AmpicillincellWall

0.039

Cephalexin20-100 ug/mL CephalexincellWall

-0.372

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.191

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.076

EMB10-20 ug/mL EthambutolcellWall

0.629

Eta12-40 ug/mL EthionamidecellWall

0.829

INH0.2-0.4 ug/mL IsoniazidcellWall

0.902

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.235

BZA0.12 mg/mL BenzamidearomaticAmides

-0.655

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.715

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.417

H2O24 mM hydrogen peroxideDNAdamaging

-0.554

Levo10 ug/mL LevofloxacinDNAdamaging

0.158

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.159

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.465

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.285

Antimycin12.5-50 ug/mL Antimycin A?

-2.114

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.210

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.213

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.273

PA8240.2-2 ug/mL PA-824?

-0.210

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.324

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

0.000

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.494

methoxatin10-20 ug/mL Methoxatin?