from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0131c/fadE1

LFCtreatmentdescriptionclass of inhibitor

-0.134

Amikacinug/mL Amikacintranslation

0.629

Cap5-10ug/mL Capreomycintranslation

0.889

Rox10-50 ug/mL Roxithromycintranslation

0.010

SM2-5 ug/mL Streptomycintranslation

-1.050

Tet5-10 ug/mL Tetracyclinetranslation

-1.246

Rif0.2-5ug/mL Rifampicintranscription

-0.152

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.046

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.106

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.086

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.385

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.781

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.656

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.577

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.364

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.134

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.888

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.228

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.465

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.963

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.270

KCN5-20 ug/mL Potassium cyaniderespiration

0.612

NaN30.2-2 mM Sodium aziderespiration

-0.011

Nigericin50 uM Nigericinrespiration

0.862

TRC10-150 ug/mL Triclosanrespiration

-0.605

TRZ10-25 ug/mL Thioridazinerespiration

-0.303

Valinomycin0.5-10 uM Valinomycinrespiration

0.227

ZnSO42 mM ZnSO4respiration

-0.047

menadione6-10 ug/mL Menadionerespiration

0.277

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.373

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.071

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.422

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.133

NRP_1Non-replicating persistence stage 1dosRassociated

0.028

Amp0.2mg/mL AmpicillincellWall

0.071

Cephalexin20-100 ug/mL CephalexincellWall

-0.077

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.256

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.586

EMB10-20 ug/mL EthambutolcellWall

0.377

Eta12-40 ug/mL EthionamidecellWall

0.376

INH0.2-0.4 ug/mL IsoniazidcellWall

0.039

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.052

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.491

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

2.535

BZA0.12 mg/mL BenzamidearomaticAmides

1.460

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.001

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.207

H2O24 mM hydrogen peroxideDNAdamaging

-0.351

Levo10 ug/mL LevofloxacinDNAdamaging

0.101

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.144

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.236

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.105

UVUV-irradiationDNAdamaging

-0.819

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.585

Antimycin12.5-50 ug/mL Antimycin A?

-0.829

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.631

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.682

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.345

PA8240.2-2 ug/mL PA-824?

0.428

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.372

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.352

Verapamil50 uM Verapamil?

-1.072

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.366

methoxatin10-20 ug/mL Methoxatin?