from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0129c/fbpC

LFCtreatmentdescriptionclass of inhibitor

-1.005

Amikacinug/mL Amikacintranslation

-0.362

Cap5-10ug/mL Capreomycintranslation

-1.003

Rox10-50 ug/mL Roxithromycintranslation

-0.802

SM2-5 ug/mL Streptomycintranslation

-1.776

Tet5-10 ug/mL Tetracyclinetranslation

-1.326

Rif0.2-5ug/mL Rifampicintranscription

-0.164

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.017

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.263

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.143

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.244

Clofazimine10-13 ug/mL Clofaziminerespiration

0.144

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.488

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.696

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.285

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.185

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.415

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.882

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.738

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.345

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.207

KCN5-20 ug/mL Potassium cyaniderespiration

0.102

NaN30.2-2 mM Sodium aziderespiration

-0.821

Nigericin50 uM Nigericinrespiration

0.802

TRC10-150 ug/mL Triclosanrespiration

0.182

TRZ10-25 ug/mL Thioridazinerespiration

-1.001

Valinomycin0.5-10 uM Valinomycinrespiration

-0.021

ZnSO42 mM ZnSO4respiration

-0.614

menadione6-10 ug/mL Menadionerespiration

-1.019

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.035

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.568

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.158

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-2.289

NRP_1Non-replicating persistence stage 1dosRassociated

1.039

Amp0.2mg/mL AmpicillincellWall

0.871

Cephalexin20-100 ug/mL CephalexincellWall

1.300

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.427

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.090

EMB10-20 ug/mL EthambutolcellWall

1.568

Eta12-40 ug/mL EthionamidecellWall

1.337

INH0.2-0.4 ug/mL IsoniazidcellWall

0.964

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.207

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.193

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.983

BZA0.12 mg/mL BenzamidearomaticAmides

0.755

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.715

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.956

H2O24 mM hydrogen peroxideDNAdamaging

-0.513

Levo10 ug/mL LevofloxacinDNAdamaging

-0.363

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.257

Novobiocin10 ug/mL NovobiocinDNAdamaging

-1.397

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.363

UVUV-irradiationDNAdamaging

-1.902

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.772

Antimycin12.5-50 ug/mL Antimycin A?

0.302

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.301

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.163

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.770

PA8240.2-2 ug/mL PA-824?

0.676

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.023

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.129

Verapamil50 uM Verapamil?

-0.178

mercaptoethanol2 mM 2-Mercaptoethanol?

0.095

methoxatin10-20 ug/mL Methoxatin?