from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0128/-

LFCtreatmentdescriptionclass of inhibitor

0.181

Amikacinug/mL Amikacintranslation

0.326

Cap5-10ug/mL Capreomycintranslation

0.507

Rox10-50 ug/mL Roxithromycintranslation

1.016

SM2-5 ug/mL Streptomycintranslation

-0.388

Tet5-10 ug/mL Tetracyclinetranslation

0.653

Rif0.2-5ug/mL Rifampicintranscription

-0.161

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.527

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.334

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.556

CPZ10-50 ug/mL Chlorpromazinerespiration

-3.068

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.470

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.714

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.223

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.993

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.835

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-2.362

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.382

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.295

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.771

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.641

Nigericin50 uM Nigericinrespiration

0.170

TRC10-150 ug/mL Triclosanrespiration

-1.195

TRZ10-25 ug/mL Thioridazinerespiration

-0.446

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.033

menadione6-10 ug/mL Menadionerespiration

-0.458

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.048

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.322

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.798

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.341

NRP_1Non-replicating persistence stage 1dosRassociated

-0.072

Amp0.2mg/mL AmpicillincellWall

0.364

Cephalexin20-100 ug/mL CephalexincellWall

-0.093

Cerulenin0.32-5 ug/mL CerulenincellWall

0.328

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.131

EMB10-20 ug/mL EthambutolcellWall

-0.539

Eta12-40 ug/mL EthionamidecellWall

-0.600

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.352

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.406

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.517

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.571

BZA0.12 mg/mL BenzamidearomaticAmides

0.791

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.201

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.935

H2O24 mM hydrogen peroxideDNAdamaging

0.060

Levo10 ug/mL LevofloxacinDNAdamaging

0.829

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.462

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.041

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.817

UVUV-irradiationDNAdamaging

-0.255

ARP41-4 ug/mL Antitubercular compound ARP4?

0.050

Antimycin12.5-50 ug/mL Antimycin A?

-2.553

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.275

PA_110-50 ug/mL Antitubercular compound PA-1?

0.307

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.890

PA8240.2-2 ug/mL PA-824?

-0.870

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.644

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.319

Verapamil50 uM Verapamil?

-1.995

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.497

methoxatin10-20 ug/mL Methoxatin?