from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0126/treS

LFCtreatmentdescriptionclass of inhibitor

-1.381

Amikacinug/mL Amikacintranslation

-2.055

Cap5-10ug/mL Capreomycintranslation

-2.221

Rox10-50 ug/mL Roxithromycintranslation

0.370

SM2-5 ug/mL Streptomycintranslation

-3.631

Tet5-10 ug/mL Tetracyclinetranslation

-2.180

Rif0.2-5ug/mL Rifampicintranscription

-0.741

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.652

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.806

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.516

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.872

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.461

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.950

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.354

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.885

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.619

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.593

Nigericin50 uM Nigericinrespiration

-0.400

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.785

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.372

menadione6-10 ug/mL Menadionerespiration

0.070

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.540

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.279

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.316

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.859

NRP_1Non-replicating persistence stage 1dosRassociated

0.467

Amp0.2mg/mL AmpicillincellWall

-0.189

Cephalexin20-100 ug/mL CephalexincellWall

0.762

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.084

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.124

EMB10-20 ug/mL EthambutolcellWall

0.397

Eta12-40 ug/mL EthionamidecellWall

0.680

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.045

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.894

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

3.916

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.047

BZA0.12 mg/mL BenzamidearomaticAmides

0.398

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.233

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.161

H2O24 mM hydrogen peroxideDNAdamaging

0.140

Levo10 ug/mL LevofloxacinDNAdamaging

0.581

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.053

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.508

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.804

Antimycin12.5-50 ug/mL Antimycin A?

0.313

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.421

PA_110-50 ug/mL Antitubercular compound PA-1?

0.053

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.252

PA8240.2-2 ug/mL PA-824?

-0.197

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.518

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.920

Verapamil50 uM Verapamil?

0.305

mercaptoethanol2 mM 2-Mercaptoethanol?

1.742

methoxatin10-20 ug/mL Methoxatin?