from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0120c/fusA2

LFCtreatmentdescriptionclass of inhibitor

-0.099

Amikacinug/mL Amikacintranslation

-0.654

Cap5-10ug/mL Capreomycintranslation

-0.627

Rox10-50 ug/mL Roxithromycintranslation

-0.840

SM2-5 ug/mL Streptomycintranslation

-1.090

Tet5-10 ug/mL Tetracyclinetranslation

0.931

Rif0.2-5ug/mL Rifampicintranscription

-0.234

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.013

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.130

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.001

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.203

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.152

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.711

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.828

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.121

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

-2.911

NaN30.2-2 mM Sodium aziderespiration

0.824

Nigericin50 uM Nigericinrespiration

0.597

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.022

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.211

menadione6-10 ug/mL Menadionerespiration

0.078

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.419

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.103

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.622

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.248

NRP_1Non-replicating persistence stage 1dosRassociated

-0.522

Amp0.2mg/mL AmpicillincellWall

-0.535

Cephalexin20-100 ug/mL CephalexincellWall

-1.149

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.084

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.132

EMB10-20 ug/mL EthambutolcellWall

-1.233

Eta12-40 ug/mL EthionamidecellWall

-1.388

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.659

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.498

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.839

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.252

BZA0.12 mg/mL BenzamidearomaticAmides

0.227

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.037

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.050

H2O24 mM hydrogen peroxideDNAdamaging

0.336

Levo10 ug/mL LevofloxacinDNAdamaging

-0.247

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.093

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.463

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.205

Antimycin12.5-50 ug/mL Antimycin A?

-0.693

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.355

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.282

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.189

PA8240.2-2 ug/mL PA-824?

-1.234

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.961

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.375

Verapamil50 uM Verapamil?

1.221

mercaptoethanol2 mM 2-Mercaptoethanol?

2.669

methoxatin10-20 ug/mL Methoxatin?