from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0098/fcoT

LFCtreatmentdescriptionclass of inhibitor

-0.814

Amikacinug/mL Amikacintranslation

-0.137

Cap5-10ug/mL Capreomycintranslation

-0.601

Rox10-50 ug/mL Roxithromycintranslation

-0.004

SM2-5 ug/mL Streptomycintranslation

-0.960

Tet5-10 ug/mL Tetracyclinetranslation

0.144

Rif0.2-5ug/mL Rifampicintranscription

-0.245

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.645

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.519

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.337

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.112

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.058

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.029

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.288

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.813

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.124

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.386

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.445

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.028

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.693

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.380

KCN5-20 ug/mL Potassium cyaniderespiration

-1.481

NaN30.2-2 mM Sodium aziderespiration

0.328

Nigericin50 uM Nigericinrespiration

-0.703

TRC10-150 ug/mL Triclosanrespiration

-1.137

TRZ10-25 ug/mL Thioridazinerespiration

0.356

Valinomycin0.5-10 uM Valinomycinrespiration

0.202

ZnSO42 mM ZnSO4respiration

0.262

menadione6-10 ug/mL Menadionerespiration

-0.264

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.363

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.884

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.015

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.608

NRP_1Non-replicating persistence stage 1dosRassociated

0.367

Amp0.2mg/mL AmpicillincellWall

0.189

Cephalexin20-100 ug/mL CephalexincellWall

0.255

Cerulenin0.32-5 ug/mL CerulenincellWall

0.082

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.641

EMB10-20 ug/mL EthambutolcellWall

-0.396

Eta12-40 ug/mL EthionamidecellWall

-0.234

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.589

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.328

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.280

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.706

BZA0.12 mg/mL BenzamidearomaticAmides

0.834

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.866

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.500

H2O24 mM hydrogen peroxideDNAdamaging

0.112

Levo10 ug/mL LevofloxacinDNAdamaging

0.560

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.312

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.175

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.632

UVUV-irradiationDNAdamaging

-1.507

ARP41-4 ug/mL Antitubercular compound ARP4?

0.540

Antimycin12.5-50 ug/mL Antimycin A?

0.005

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.187

PA_110-50 ug/mL Antitubercular compound PA-1?

0.486

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.266

PA8240.2-2 ug/mL PA-824?

-2.315

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.005

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.289

Verapamil50 uM Verapamil?

0.384

mercaptoethanol2 mM 2-Mercaptoethanol?

0.092

methoxatin10-20 ug/mL Methoxatin?